Rationale: T-cell responses during tuberculosis (TB) help contain Mycobacterium tuberculosis
in vivo but also cause collateral damage to host tissues. Immune regulatory mechanisms …

Background Lung delivery of plasmid DNA encoding the CFTR gene complexed with a
cationic liposome is a potential treatment option for patients with cystic fibrosis. We aimed to …

Inefficient inhaler technique is a common problem resulting in poor drug delivery, decreased
disease control and increased inhaler use. The aim of this study was to assess patients' use …

1. To determine if negative upper airway pressure causes reflex pharyngeal dilator muscle
activation, we used intra‐oral bipolar surface electrodes to record genioglossus …

In cystic fibrosis (CF), mutation of the cystic fibrosis transmembrane conductance regulator (CFTR)
gene results in defective transepithelial ion transport, leading to life shortening …

Distinct IFN-γ and IL-2 profiles of Ag-specific CD4+ T cells have recently been associated
with different clinical disease states and Ag loads in viral infections. We assessed the kinetics …

Background: The loss of cystic fibrosis transmembrane conductance regulator (CFTR) mediated
chloride conductance does not fully explain the diverse pathologies evident in patients …

Background: Lung clearance index (LCI) is a sensitive marker of early lung disease in children
but has not been assessed in adults. Measurement is hindered by the complexity of the …

INTRODUCTION Need for new recommendations for managing passengers with respiratory
disease planning air travel Since the first British Thoracic Society (BTS) recommendations …

Background Despite a recent resurgence in the incidence of bovine tuberculosis in UK cattle
herds, no associated rise in the number of cases in man has been noted. Disease due to …