The T4 gene encodes the AIDS virus receptor and is expressed in the immune system and the brain
PJ Maddon, AG Dalgleish, JS McDougal, PR Clapham… - Cell, 1986 - cell.com
The isolation of clones encoding the human surface protein T4, and the expression of the
T4 gene in new cellular environments, have enabled us to examine the role of this protein in …
T4 gene in new cellular environments, have enabled us to examine the role of this protein in …
Binding of HTLV-III/LAV to T4+ T Cells by a Complex of the 110K Viral Protein and the T4 Molecule
JS McDougal, MS Kennedy, JM Sligh, SP Cort… - Science, 1986 - science.org
Human T-lymphotropic virus type III (HTLV-III) or lymphadenopathy-associated virus (LAV)
is tropic for human T cells with the helper-inducer phenotype, as defined by reactivity with …
is tropic for human T cells with the helper-inducer phenotype, as defined by reactivity with …
Quantitative detection of increasing HIV type 1 antibodies after seroconversion: a simple assay for detecting recent HIV infection and estimating incidence
…, K Choopanya, TD Mastro, JS McDougal - AIDS research and …, 2002 - liebertpub.com
We have devised a simple enzyme immunoassay (EIA) that detects increasing levels of anti-HIV
IgG after seroconversion and can be used for detecting recent HIV-1 infection. Use of a …
IgG after seroconversion and can be used for detecting recent HIV-1 infection. Use of a …
Disinfection and inactivation of the human T lymphotropic virus type III/lymphadenopathy-associated virus
LS Martin, JS McDougal, SL Loskoski - The Journal of infectious diseases, 1985 - JSTOR
Materials and Methods Virus and virus propagation. HTLV-III/LAV was propagated in
phytohemagglutinin-stimulated normal hu-man lymphocytes (PHA blasts) that were cultured in …
phytohemagglutinin-stimulated normal hu-man lymphocytes (PHA blasts) that were cultured in …
Soluble form of CD4 (T4) protein inhibits AIDS virus infection
KC Deen, JS McDougal, R Inacker… - Nature, 1988 - nature.com
CD4 (T4) is a glycoprotein of relative molecular mass 55,000 (M r 55K) on the surface of T
lymphocytes which is thought to interact with class II MHC (major histocompatibility complex) …
lymphocytes which is thought to interact with class II MHC (major histocompatibility complex) …
Expression and Characterization of CD4-IgG2, a Novel Heterotetramer That Neutralizes Primary HIV Type 1 Isolates
…, MC GAUDUIN, RA Koup, JS McDOUGAL… - AIDS research and …, 1995 - liebertpub.com
CD4-IgG 2 is a novel fusion protein comprising human IgG 2 in which the Fv portions of both
heavy and light chains have been replaced by the V1 and V2 domains of human CD4. This …
heavy and light chains have been replaced by the V1 and V2 domains of human CD4. This …
Identification of the residues in human CD4 critical for the binding of HIV
…, QJ Sattentau, PR Clapham, RA Weiss, JS McDougal… - Cell, 1989 - cell.com
The CD4 molecule is a T cell surface glycoprotein that interacts with high affinity with the
envelope glycoprotein of the human immunodeficiency virus, HIV, thus serving as a cellular …
envelope glycoprotein of the human immunodeficiency virus, HIV, thus serving as a cellular …
Cellular tropism of the human retrovirus HTLV-III/LAV. I. Role of T cell activation and expression of the T4 antigen.
JS McDougal, A Mawle, SP Cort… - … (Baltimore, Md.: 1950 …, 1985 - journals.aai.org
In cultures of normal human lymphocytes infected with the human retrovirus HTLV-III/LAV,
detectable cytoplasmic virus appears and then disappears in a proportion (1 to 10%) of cells, …
detectable cytoplasmic virus appears and then disappears in a proportion (1 to 10%) of cells, …
[BOOK][B] Guidelines for performing single-platform absolute CD4+ T-cell determinations with CD45 gating for persons infected with human immunodeficiency virus
FF Mandy, JKA Nicholson, JS McDougal, GH Mazurek… - 2003 - cdc.gov
These guidelines were developed by CDC for laboratorians who perform immunophenotyping
for detection and enumeration of CD4+ T-cells and other lymphocyte subsets in persons …
for detection and enumeration of CD4+ T-cells and other lymphocyte subsets in persons …
Inhibition of HIV-1 infectivity by zinc-ejecting aromatic C-nitroso compounds
…, LO Arthur, JS McDougal, SL Orloff, J Mendeleyev… - Nature, 1993 - nature.com
RETROVIRAL nucleocapsid and gag-precursor proteins from all known strains of retroviruses
contain one or two copies of an invariant sequence, Cys-X 2 -Cys-X 4 -His-X 4 -Cys 1,2 , …
contain one or two copies of an invariant sequence, Cys-X 2 -Cys-X 4 -His-X 4 -Cys 1,2 , …