Background Lung delivery of plasmid DNA encoding the CFTR gene complexed with a
cationic liposome is a potential treatment option for patients with cystic fibrosis. We aimed to …

Background: Lung clearance index (LCI) is a sensitive marker of early lung disease in children
but has not been assessed in adults. Measurement is hindered by the complexity of the …

Rationale: Markers of inflammatory activity are important for assessment and management of
many respiratory diseases. Markers that are currently unrecognized may be more valuable …

We have recently shown that non-viral gene therapy can stabilise the decline of lung function
in patients with cystic fibrosis (CF). However, the effect was modest, and more potent gene …

Background Clinical trials in cystic fibrosis (CF) have been hindered by the paucity of well
characterised and clinically relevant outcome measures. Aim To evaluate a range of …

Background: In adults with asthma, ventilation heterogeneity, independent of inflammation,
has been hypothesised to be associated with airway remodelling. Bronchial biopsy in …

Rationale: Ongoing efforts to improve pulmonary gene transfer thereby enabling gene therapy
for the treatment of lung diseases, such as cystic fibrosis (CF), has led to the assessment …

Background Induced sputum cytology and protein biomarkers can be used to assess airways
inflammation. Increases in sputum iron have been described in inflammatory lung disease. …

The UK Cystic Fibrosis Gene Therapy Consortium has been working towards clinical gene
therapy for patients with cystic fibrosis for several years. We have recently embarked on a …

The vast majority of treatments for cystic fibrosis (CF) target the downstream consequences
of the disease and are incompletely effective. The success of the CF transmembrane …