Ikaros family DNA-binding proteins are critical regulators of B-cell development. Because
the current knowledge of Ikaros targets in B-cell progenitors is limited, we have identified …

Objective The A allele of the PD1.3 single‐nucleotide polymorphism (SNP) on the programmed
cell death gene PDCD1 was markedly more frequent in patients with systemic lupus …

Multi-omics approaches use a diversity of high-throughput technologies to profile the different
molecular layers of living cells. Ideally, the integration of this information should result in …

Molecular profiling of circulating cell-free DNA (cfDNA) has shown utility for the management
of colorectal cancer (CRC). TruSight Tumor 170 (TST170) is a next-generation sequencing (…

10.7554/eLife.22767.001 Turning genes on and off is essential for development and
homeostasis, yet little is known about the sequence and causal role of chromatin state changes …

Importance Cardiac dysfunction and myocarditis have emerged as serious complications of
multisystem inflammatory syndrome in children (MIS-C) and vaccines against SARS-CoV-2. …

OBJECTIVE: To investigate whether the 3 most common mutations in the NOD2 gene that
confer susceptibility to Crohn's disease (CD) are also associated with ankylosing spondylitis (…

Simple Summary The evaluation of RAS mutations from plasma circulating tumour DNA (ctDNA)
has emerged as an efficient approach to guide therapeutic decisions in the treatment of …

The differentiation of self-renewing progenitor cells requires not only the regulation of
lineage- and developmental stage–specific genes but also the coordinated adaptation of …

Ikaros and Foxp1 are transcription factors that play key roles in normal lymphopoiesis and
lymphoid malignancies. We describe a novel physical and functional interaction between the …