Current understanding of rheumatoid arthritis therapy

I Colmegna, BR Ohata… - Clinical Pharmacology & …, 2012 - Wiley Online Library
Progress in understanding the cellular and molecular mechanisms of rheumatoid arthritis (RA),
together with the availability of new therapies, has changed the way we think about RA. …

Telomerase insufficiency in rheumatoid arthritis

H Fujii, L Shao, I Colmegna… - Proceedings of the …, 2009 - National Acad Sciences
In rheumatoid arthritis (RA), chronically stimulated T lymphocytes sustain tissue-destructive
joint inflammation. Both naïve and memory T cells in RA are prematurely aged with …

HLA-B27-associated reactive arthritis: pathogenetic and clinical considerations

I Colmegna, R Cuchacovich… - Clinical microbiology …, 2004 - Am Soc Microbiol
Current evidence supports the concept that reactive arthritis (ReA) is an immune-mediated
synovitis resulting from slow bacterial infections and showing intra-articular persistence of …

Deficiency of the DNA repair enzyme ATM in rheumatoid arthritis

L Shao, H Fujii, I Colmegna, H Oishi… - Journal of Experimental …, 2009 - rupress.org
In rheumatoid arthritis (RA), dysfunctional T cells sustain chronic inflammatory immune
responses in the synovium. Even unprimed T cells are under excessive replication pressure, …

A proinflammatory secretome mediates the impaired immunopotency of human mesenchymal stromal cells in elderly patients with atherosclerosis

…, S Nadeau, F Rodier, I Colmegna - Stem cells …, 2017 - academic.oup.com
Inflammation plays a pivotal role in the initiation and progression of atherosclerosis (ATH).
Due to their potent immunomodulatory properties, mesenchymal stromal cells (MSCs) are …

Systematic review of recommendations on the use of disease‐modifying antirheumatic drugs in patients with rheumatoid arthritis and cancer

MA Lopez‐Olivo, I Colmegna… - Arthritis Care & …, 2020 - Wiley Online Library
Objective To evaluate consensus recommendations regarding management of rheumatoid
arthritis ( RA ) in patients with cancer. Methods We searched electronic databases, guideline …

[HTML][HTML] Human multipotent mesenchymal stromal cells cytokine priming promotes RAB27B-regulated secretion of small extracellular vesicles with immunomodulatory …

…, M Lora, D Shum-Tim, J Rak, I Colmegna - Stem Cell Research & …, 2020 - Springer
Background The paracrine effects of multipotent mesenchymal stromal cells (MSCs) are
mediated by their secretome composed by soluble factors (ie, cytokines, growth factors, …

Defective proliferative capacity and accelerated telomeric loss of hematopoietic progenitor cells in rheumatoid arthritis

I Colmegna, A Diaz‐Borjon, H Fujii… - Arthritis & …, 2008 - Wiley Online Library
Objective In rheumatoid arthritis (RA), telomeres of lymphoid and myeloid cells are age‐inappropriately
shortened, suggesting excessive turnover of hematopoietic precursor cells (…

Autoimmune sensorineural hearing loss: the otology–rheumatology interface

T Mijovic, A Zeitouni, I Colmegna - Rheumatology, 2013 - academic.oup.com
Autoimmune sensorineural hearing loss (SNHL) is a rare clinical entity characterized by a
progressive fluctuating bilateral asymmetric SNHL that develops over several weeks to months…

ERK-dependent T cell receptor threshold calibration in rheumatoid arthritis

…, P Deshpande, S Pryshchep, I Colmegna… - The Journal of …, 2009 - journals.aai.org
Immune responses to citrullinated neoantigens and clinical efficacy of costimulation blockade
indicate a general defect in maintaining T cell tolerance in rheumatoid arthritis (RA). To …