Background Intraoperative hypotension (IOH) during non-cardiac surgery is common and
associated with major adverse kidney, neurological and cardiac events and even death. Given …

The delivery of drugs through targeted nanocarriers that are internalized by cells provides
an alternative route to diffusion of drugs into cells. Growth factor or vitamin interactions with …

A literature search was carried out to summarize the existing scientific evidence concerning
occurrence, causes, and consequences of multimorbidity (the coexistence of multiple …

A large class of classical combinatorial problems, including most of the difficult problems in
the literature of network flows and computational graph theory, are shown to be equivalent, in …

Let C = (V,E) be a digraph with n vertices. Let f be a function from E into the real numbers,
associating with each edge e ∈ E a weight ƒ(e) . Given any sequence of edges σ = e 1 ,e 2 ,…,…

A highly efficient algorithm (HK) devised by Held and Karp for solving the symmetric
traveling-salesman problem was presented at the 7th Mathematical Programming Symposium in …

… and minimum spanning trees, Held and Karp showed that finding an optimally weighted 1-…
In this paper we show that the Held-Karp 1-trees have a certain monotonicity property: given …

… The Held-Karp (HK) lower bound is the solution to the linear … techniques first suggested by
Held and Karp. In this paper, we … that the ratio of the Held-Karp bound to√ N approaches a …

The worldwide incidence, morbidity, and mortality of allergic asthma are increasing. The
pathophysiological features of allergic asthma are thought to result from the aberrant expansion …

Throughout the 1960s I worked on combinatorial optimization problems including logic circuit
design with Paul Roth and assembly line balancing and the traveling salesman problem …