The infrapatellar fat pad of patients with osteoarthritis has an inflammatory phenotype

IR Klein-Wieringa, M Kloppenburg… - Annals of the …, 2011 - ard.bmj.com
Objectives Obesity is a risk factor for the development of osteoarthritis (OA) in hands and
knees. Adipose tissue can secrete different adipokines with powerful immunomodulatory effects…

Inflammatory cells in patients with endstage knee osteoarthritis: a comparison between the synovium and the infrapatellar fat pad

IR Klein-Wieringa, BJE de Lange-Brokaar… - The Journal of …, 2016 - jrheum.org
Objective. To get a better understanding of inflammatory pathways active in the osteoarthritic
(OA) joint, we characterized and compared inflammatory cells in the synovium and the …

Baseline serum adipokine levels predict radiographic progression in early rheumatoid arthritis

IR KleinWieringa, MPM van der Linden… - Arthritis & …, 2011 - Wiley Online Library
Baseline serum adipokine levels predict radiographic progression in early rheumatoid
arthritis - KleinWieringa - 2011 - Arthritis & Rheumatism - Wiley Online Library … Klein-Wieringa

Adipocytes modulate the phenotype of human macrophages through secreted lipids

IR Klein-Wieringa, SN Andersen… - The Journal of …, 2013 - journals.aai.org
Klein-Wieringa; … Klein-WieringaKlein-Wieringa, Stefan N. Andersen, Joanneke C.
Kwekkeboom, Martin Giera, Badelog JE de Lange-Brokaar, Gerjo JVM van Osch, Anne-Marie …

Update on the treatment of nonsystemic juvenile idiopathic arthritis including treatment-to-target: is (drug-free) inactive disease already possible?

IR Klein-Wieringa, DMC Brinkman… - Current Opinion in …, 2020 - journals.lww.com
Remission can be achieved and sustained in (some) JIA patients, regardless of initial treatment.
Cornerstone principles in the management of nonsystemic JIA treatment are early start …

[HTML][HTML] Lack of high BMI-related features in adipocytes and inflammatory cells in the infrapatellar fat pad (IFP)

AJ de Jong, IR Klein-Wieringa, SN Andersen… - Arthritis research & …, 2017 - Springer
Background Obesity is associated with the development and progression of osteoarthritis (OA).
Although the infrapatellar fat pad (IFP) could be involved in this association, due to its …

Are baseline high molecular weight adiponectin levels associated with radiographic progression in rheumatoid arthritis and osteoarthritis?

IR Klein-Wieringa, SN Andersen… - The Journal of …, 2014 - jrheum.org
Objective. To investigate whether high molecular weight adiponectin (hmwAPN) mediates
the associations of total adiponectin (totAPN) with radiographic progression in rheumatoid …

Inflammatory features of infrapatellar fat pad in rheumatoid arthritis versus osteoarthritis reveal mostly qualitative differences

AJ de Jong, IR Klein-Wieringa… - Annals of the …, 2018 - ard.bmj.com
Rheumatoid arthritis (RA) and osteoarthritis (OA) are characterised by joint destruction. In
both diseases, inflammation is implicated; however, RA is generally associated with more …

[HTML][HTML] Synovial CD4+ T cells associate with pain in osteoarthritis: is there a role for fatty acids?

…, BJ De Lange-Brokaar, IR Klein-Wieringa… - Osteoarthritis and …, 2016 - oarsijournal.com
Purpose: Synovitis is associated with pain in patients with knee osteoarthritis (OA). However,
the cellular and molecular mechanisms underlying this association remain unclear. …

Adiponectin is a predictor for radiographic progression in early RA patients, independently of anti-CCP antibodies

IR Klein-Wieringa, MPM Van der Linden… - Annals of the …, 2011 - ard.bmj.com
Background and objectives Adipose tissue can secrete soluble mediators (adipokines) with
potent immune regulatory functions. Some adipokines have been previously associated with …