Classification, diagnosis, and management of idiopathic inflammatory myopathies

IN Lazarou, PA Guerne - The journal of Rheumatology, 2013 - jrheum.org
The detection and characterization of a large array of autoantibodies, including at least 8
different antisynthetase, anti-SRP, -200/100 (HMGCR), -Mi-2, -CADM-140 (MDA5), -SAE, -p155…

Structure, function, and regulation of mitofusin‐2 in health and disease

G Chandhok, M Lazarou, B Neumann - Biological Reviews, 2018 - Wiley Online Library
Mitochondria are highly dynamic organelles that constantly migrate, fuse, and divide to regulate
their shape, size, number, and bioenergetic function. Mitofusins (Mfn1/2), optic atrophy 1 …

[HTML][HTML] Assembly of mitochondrial complex I and defects in disease

M Lazarou, DR Thorburn, MT Ryan… - Biochimica et Biophysica …, 2009 - Elsevier
Isolated complex I deficiency is the most common cause of respiratory chain dysfunction.
Defects in human complex I result in energy generation disorders and they are also implicated …

Incidence of adverse drug reactions in hospitalized patients: a meta-analysis of prospective studies

J Lazarou, BH Pomeranz, PN Corey - Jama, 1998 - jamanetwork.com
Objective.—To estimate the incidence of serious and fatal adverse drug reactions (ADR) in
hospital patients.Data Sources.—Four electronic databases were searched from 1966 to 1996…

Relationship between trinucleotide repeat expansion and phenotypic variation in Huntington's disease

…, JC MacMillan, JP Cheadle, I Fenton, LP Lazarou… - Nature …, 1993 - nature.com
The molecular analysis of a specific CAG repeat sequence in the Huntington's disease
gene in 440 Huntington's disease patients and 360 normal controls reveals a range of 30–70 …

Arginine enhances wound healing and lymphocyte immune responses in humans.

A Barbul, SA Lazarou, DT Efron, HL Wasserkrug… - Surgery, 1990 - europepmc.org
Arginine has been shown to enhance wound healing and T-cell-mediated immune function
in rodents. In this study the effect of oral arginine supplementation on human collagen …

[PDF][PDF] Role of PINK1 binding to the TOM complex and alternate intracellular membranes in recruitment and activation of the E3 ligase Parkin

M Lazarou, SM Jin, LA Kane, RJ Youle - Developmental cell, 2012 - cell.com
Mutations in the mitochondrial kinase PINK1 and the cytosolic E3 ligase Parkin can cause
Parkinson's disease. Damaged mitochondria accumulate PINK1 on the outer membrane …

Mitochondrial respiratory chain supercomplexes are destabilized in Barth Syndrome patients

M McKenzie, M Lazarou, DR Thorburn… - Journal of molecular …, 2006 - Elsevier
Mutations in the human TAZ gene are associated with Barth Syndrome, an often fatal X-linked
disorder that presents with cardiomyopathy and neutropenia. The TAZ gene encodes …

Optimal placement of wind turbines in a wind park using Monte Carlo simulation

G Marmidis, S Lazarou, E Pyrgioti - Renewable energy, 2008 - Elsevier
In the present study, a novel procedure is introduced for the optimal placement and arrangement
of wind turbines in a wind park. In this approach a statistical and mathematical method …

Analysis of the assembly profiles for mitochondrial-and nuclear-DNA-encoded subunits into complex I

M Lazarou, M McKenzie, A Ohtake… - … and cellular biology, 2007 - Taylor & Francis
Complex I of the respiratory chain is composed of at least 45 subunits that assemble
together at the mitochondrial inner membrane. Defects in human complex I result in energy …