User profiles for I. C. SCOTT

Ian C. Scott

- Verified email at sickkids.ca - Cited by 3572

Ian C Scott

- Verified email at keele.ac.uk - Cited by 2499

[HTML][HTML] The impact of rheumatoid arthritis on quality-of-life assessed using the SF-36: a systematic review and meta-analysis

F Matcham, IC Scott, L Rayner, M Hotopf… - Seminars in arthritis and …, 2014 - Elsevier
Objective The assessment of health-related quality-of-life (HRQoL) in rheumatoid arthritis (RA)
is becoming increasingly common in both research and clinical practice. One of the most …

Thromboembolism with Janus kinase (JAK) inhibitors for rheumatoid arthritis: how real is the risk?

IC Scott, SL Hider, DL Scott - Drug safety, 2018 - Springer
… Ian Scott is the statistician on a retrospective study entitled “… Scott will be receiving funding
for this work from Guy’s and St … Scott has received fees for consulting and giving educational …

The protective effect of alcohol on developing rheumatoid arthritis: a systematic review and meta-analysis

IC Scott, R Tan, D Stahl, S Steer, CM Lewis… - …, 2013 - academic.oup.com
Objectives. Our aim was to establish whether alcohol protects against RA development and
to determine whether this effect is influenced by alcohol dose, duration and serological …

Genetic and cellular analyses of zebrafish atrioventricular cushion and valve development

D Beis, T Bartman, SW Jin, IC Scott, LA D'Amico… - 2005 - journals.biologists.com
Defects in cardiac valve morphogenesis and septation of the heart chambers constitute some
of the most common human congenital abnormalities. Some of these defects originate from …

Multi-ancestry genome-wide association analyses identify novel genetic mechanisms in rheumatoid arthritis

…, T Amariuta, CL Too, VA Laufer, IC Scott… - Nature …, 2022 - nature.com
Rheumatoid arthritis (RA) is a highly heritable complex disease with unknown etiology. Multi-ancestry
genetic research of RA promises to improve power to detect genetic signals, fine-…

[HTML][HTML] Multiple bone morphogenetic protein 1-related mammalian metalloproteinases process pro-lysyl oxidase at the correct physiological site and control lysyl …

MI Uzel, IC Scott, H Babakhanlou-Chase… - Journal of Biological …, 2001 - ASBMB
Lysyl oxidase catalyzes the final enzymatic step required for collagen and elastin cross-linking
in extracellular matrix biosynthesis. Pro-lysyl oxidase is processed by procollagen C-…

Mammalian BMP-1/Tolloid-related metalloproteinases, including novel family member mammalian Tolloid-like 2, have differential enzymatic activities and distributions …

IC Scott, IL Blitz, WN Pappano, Y Imamura… - Developmental …, 1999 - Elsevier
… 2, preliminary results show it to have proteolytic activity against other substrates such as
prolysyl oxidase (IC Scott, M. Uzel, PC Trackman, and DS Greenspan, unpublished results). …

The HAND1 basic helix-loop-helix transcription factor regulates trophoblast differentiation via multiple mechanisms

IC Scott, L Anson-Cartwright, P Riley… - … and cellular biology, 2000 - Taylor & Francis
… Indeed we have found that cotransfection of ITF2 does not block the ability of HAND1 to
promote giant cell differentiation (IC Scott, unpublished results). Further work will be required to …

[HTML][HTML] Oxidation of the alarmin IL-33 regulates ST2-dependent inflammation

ES Cohen, IC Scott, JB Majithiya, L Rapley… - Nature …, 2015 - nature.com
In response to infections and irritants, the respiratory epithelium releases the alarmin interleukin
(IL)-33 to elicit a rapid immune response. However, little is known about the regulation …

[HTML][HTML] Chromatin remodelling complex dosage modulates transcription factor function in heart development

…, P Chambon, DYR Stainier, KS Pollard, IC Scott… - Nature …, 2011 - nature.com
Dominant mutations in cardiac transcription factor genes cause human inherited congenital
heart defects (CHDs); however, their molecular basis is not understood. Interactions …