The 620W allelic variant of the intracellular tyrosine phosphatase, PTPN22, is associated with
a number of different autoimmune disorders, and this provides direct evidence for common …

Human genetic studies into rheumatoid arthritis (RA) have uncovered more than 100 genetic
loci associated with susceptibility to RA and have refined the RA-association model for HLA …

A major challenge in human genetics is to devise a systematic strategy to integrate disease-associated
variants with diverse genomic and biological data sets to provide insight into …

Background Rheumatoid arthritis is a chronic inflammatory disease with a substantial genetic
component. Susceptibility to disease has been linked with a region on chromosome 2q. …

The genetic association of the major histocompatibility complex (MHC) to rheumatoid arthritis
risk has commonly been attributed to alleles in HLA-DRB1. However, debate persists …

Rheumatoid arthritis (RA) is a highly heritable complex disease with unknown etiology. Multi-ancestry
genetic research of RA promises to improve power to detect genetic signals, fine-…

Systemic lupus erythematosus (SLE) has a strong but incompletely understood genetic
architecture. We conducted an association study with replication in 4,478 SLE cases and 12,656 …

Objective Smoking is associated with rheumatoid arthritis (RA) in individuals with the HLA–DRB1
shared epitope (SE). SE alleles have been shown to be predominantly associated with …

Objective Anticitrullinating autoantibodies are specific markers for rheumatoid arthritis (RA).
A functional haplotype of 4 exonic single‐nucleotide polymorphisms (SNPs) in a …

… Hye-Soon Lee … Hye-Soon Lee … Hye-Soon Lee had full access to all of the data in the
study and takes responsibility for the integrity of the data and the accuracy of the data analysis. …