User profiles for Hugues Allard-Chamard

Hugues Allard-Chamard

University de Sherbrooke
Verified email at USherbrooke.ca
Cited by 1393

[PDF][PDF] Loss of Bcl-6-expressing T follicular helper cells and germinal centers in COVID-19

…, HH Kuo, J Boucau, JR Farmer, H Allard-Chamard… - Cell, 2020 - cell.com
Humoral responses in coronavirus disease 2019 (COVID-19) are often of limited durability,
as seen with other human coronavirus epidemics. To address the underlying etiology, we …

Identification of galectin-3 as an autoantigen in patients with IgG4-related disease

…, V Mahajan, G Ganesh, H Allard-Chamard… - Journal of Allergy and …, 2019 - Elsevier
… AlSalem MBBS, MMSc b c ∗ , Hamid Mattoo PhD b , Emanuel Della-Torre MD, PhD b d ,
Vinay Mahajan MBBS, PhD b e , Gayathri Ganesh BS b , Hugues Allard-Chamard MD, PhD b , …

[HTML][HTML] Cytotoxic CD4+ T lymphocytes may induce endothelial cell apoptosis in systemic sclerosis

…, H Mattoo, J Kers, H Allard-Chamard… - The Journal of …, 2020 - Am Soc Clin Investig
Systemic sclerosis (SSc) is an autoimmune fibrotic disease whose pathogenesis is poorly
understood and lacks effective therapies. We undertook quantitative analyses of T cell …

CD4+ and CD8+ cytotoxic T lymphocytes may induce mesenchymal cell apoptosis in IgG4-related disease

…, H Mattoo, J Kers, H Allard-Chamard… - Journal of Allergy and …, 2021 - Elsevier
Background IgG 4 -related disease (IgG 4 -RD) is an immune-mediated fibrotic disorder that
has been linked to CD4 + cytotoxic T lymphocytes (CD4 + CTLs). The effector phenotype of …

Interleukin-15 in autoimmunity

H Allard-Chamard, HK Mishra, M Nandi, M Mayhue… - Cytokine, 2020 - Elsevier
Interleukin-15 (IL-15) is a member of the IL-2 family of cytokines, which use receptor complexes
containing the common gamma (γ c ) chain for signaling. IL-15 plays important roles in …

ADE and hyperinflammation in SARS-CoV2 infection-comparison with dengue hemorrhagic fever and feline infectious peritonitis

M Cloutier, M Nandi, AU Ihsan, HA Chamard… - Cytokine, 2020 - Elsevier
The COVID-19 pandemic has rapidly spread around the world with significant morbidity and
mortality in a subset of patients including the elderly. The poorer outcomes are associated …

Evaluation of the safety, efficacy, and mechanism of action of obexelimab for the treatment of patients with IgG4-related disease: an open-label, single-arm, single …

…, B Burington, H Liu, H Allard-Chamard… - The Lancet …, 2023 - thelancet.com
Background Obexelimab is a bifunctional, non-cytolytic, humanised monoclonal antibody
that binds CD19 and Fc gamma receptor IIb to inhibit B cells, plasmablasts, and CD19-…

CD4+ CTLs in fibrosing mediastinitis linked to Histoplasma capsulatum

H Allard-Chamard, F Alsufyani, N Kaneko… - The Journal of …, 2021 - journals.aai.org
Although fibrotic disorders are frequently assumed to be linked to T H2 cells, quantitative tissue
interrogation studies have rarely been performed to establish this link and certainly many …

[HTML][HTML] B1a and B2 cells are characterized by distinct CpG modification states at DNMT3A-maintained enhancers

…, V Viswanadham, GJ Yuen, H Allard-Chamard… - Nature …, 2021 - nature.com
The B1 and B2 lineages of B cells contribute to protection from pathogens in distinct ways.
The role of the DNA CpG methylome in specifying these two B-cell fates is still unclear. Here …

[PDF][PDF] Extrafollicular IgD− CD27− CXCR5− CD11c− DN3 B cells infiltrate inflamed tissues in autoimmune fibrosis and in severe COVID-19

H Allard-Chamard, N Kaneko, A Bertocchi, N Sun… - Cell Reports, 2023 - cell.com
Although therapeutic B cell depletion dramatically resolves inflammation in many diseases
in which antibodies appear not to play a central role, distinct extrafollicular pathogenic B cell …