Mutations and common polymorphisms in ADAMTS13 gene responsible for von Willebrand factor-cleaving protease activity

…, H Ishizashi, M Funato, H Tamai… - Proceedings of the …, 2002 - National Acad Sciences
von Willebrand factor (VWF) is synthesized primarily in vascular endothelial cells and secreted
into the plasma as unusually large VWF multimers. Normally, these multimers are quickly …

Free-radical chain oxidation of rat red blood cells by molecular oxygen and its inhibition by α-tocopherol

M Miki, H Tamai, M Mino, Y Yamamoto, E Niki - Archives of Biochemistry …, 1987 - Elsevier
The oxidation of rat red blood cells (RBC) by molecular oxygen was performed in an aqueous
suspension with an azo compound as a free-radical initiator. The RBC were oxidized at a …

Greater oxidative stress in healthy young men compared with premenopausal women

…, N Suematsu, M Tsuchihashi, H Tamai… - … , and vascular biology, 2002 - Am Heart Assoc
Coronary risk factors, including age, hypertension, diabetes mellitus, hyperlipidemia, and
smoking, are associated with enhanced oxidative stress, which is implicated as a potential …

Vitamin E decreases bone mass by stimulating osteoclast fusion

…, S Sunamura, T Kodama, H Takayanagi, H Tamai… - Nature medicine, 2012 - nature.com
Bone homeostasis is maintained by the balance between osteoblastic bone formation and
osteoclastic bone resorption 1 , 2 , 3 . Osteoclasts are multinucleated cells that are formed by …

Parietal dysfunction in developmental coordination disorder: a functional MRI study

M Kashiwagi, S Iwaki, Y Narumi, H Tamai, S Suzuki - Neuroreport, 2009 - journals.lww.com
We aimed to detect the mechanisms underlying clumsiness in children with developmental
coordination disorder (DCD). A functional magnetic resonance imaging study of a visuomotor …

α-Tocopherol suppresses lipid peroxidation and behavioral and cognitive impairments in the Ts65Dn mouse model of Down syndrome

…, N Ishida, Y Hagihara, H Iwahashi, H Tamai… - Free Radical Biology …, 2011 - Elsevier
It is widely accepted that oxidative stress is involved in the pathogenesis of Down syndrome,
but the effectiveness of antioxidant treatment remains inconclusive. We tested whether …

Fecal calprotectin is a useful marker for disease activity in pediatric patients with inflammatory bowel disease

…, E Kimura, K Inoue, A Andoh, H Tamai - Digestive diseases and …, 2011 - Springer
Background Studies evaluating the correlation between endoscopic disease activity and
noninvasive markers are scarce in inflammatory bowel disease (IBD). Aim The aim of this study …

[HTML][HTML] Functional analysis of PTPN11/SHP-2 mutants identified in Noonan syndrome and childhood leukemia

…, F Takada, K Nishio, M Sakurai, H Tamai… - Journal of human …, 2005 - nature.com
Noonan syndrome (NS) is characterized by short stature, characteristic facial features, and
heart defects. Recently, missense mutations of PTPN11, the gene encoding protein tyrosine …

Vigintiphobia, unbound bilirubin, and auditory brainstem responses

M Funato, H Tamai, S Shimada, H Nakamura - Pediatrics, 1994 - publications.aap.org
Objective. The management of nonhemolytic hyperbilirubinemia in term newborns is
controversial. To evaluate the usefulness of serum unbound bilirubin concentrations (UBCs) in the …

Age-specific differences in outcomes after out-of-hospital cardiac arrests

…, T Nishiuchi, Y Hayashi, A Hiraide, H Tamai… - …, 2011 - publications.aap.org
OBJECTIVE: We assessed out-of-hospital cardiac arrests (OHCAs) for various pediatric age
groups. METHODS: This prospective, population-based, observational study included all …