Background— Cardiac transthyretin (ATTR) amyloidosis is a progressive and fatal
cardiomyopathy for which several promising therapies are in development. The diagnosis is …

Background Deposition of amyloid fibrils derived from circulating acute-phase reactant serum
amyloid A protein (SAA) causes systemic AA amyloidosis, a serious complication of many …

Background The cryopyrin-associated periodic syndrome (CAPS) is a rare inherited inflammatory
disease associated with overproduction of interleukin-1. Canakinumab is a human anti…

Objective Mutations in the NALP3/CIAS1/PYPAF1 gene are associated with the autoinflammatory
diseases Muckle‐Wells syndrome (MWS), familial cold autoinflammatory syndrome (…

Background Hereditary, autosomal dominant amyloidosis, caused by mutations in the genes
encoding transthyretin, fibrinogen A α-chain, lysozyme, or apolipoprotein AI, is thought to …

Background Adult-onset inflammatory syndromes often manifest with overlapping clinical
features. Variants in ubiquitin-related genes, previously implicated in autoinflammatory disease…

Monoclonal immunoglobulin light chains are deposited as amyloid fibrils in systemic AL (primary)
amyloidosis, but the underlying plasma cell dyscrasias are often difficult to detect or …

Background— The prognosis and treatment of the 2 main types of cardiac amyloidosis,
immunoglobulin light chain (AL) and transthyretin (ATTR) amyloidosis, are substantially …

To the Editor: Studies of hereditary inflammatory disorders have identified novel genes and
pathways that may be involved in inflammation and apoptosis generally. Mutations in one …

Objective Familial cold urticaria (FCU) and Muckle‐Wells syndrome (MWS) are dominantly
inherited autoinflammatory disorders that cause rashes, fever, arthralgia, and in some …