Glomerular disease, be it primary or secondary, occurring in the setting of systemic autoimmune
diseases, infections, drugs, or malignancy, affects individuals of all ages. In most kidney …

The Kidney Disease: Improving Global Outcomes (KDIGO) Clinical Practice Guideline for the
Management of Glomerular Diseases is an update to the KDIGO 2012 guideline. The aim is …

Proteinuria has been shown to be an adverse prognostic factor in IgA nephropathy. The benefit
of achieving a partial remission of proteinuria, however, has not been well described. We …

IgA nephropathy (IgAN) is a leading cause of CKD and renal failure. Recent international
collaborative efforts have led to important discoveries that have improved our understanding of …

Background B-cell anomalies play a role in the pathogenesis of membranous nephropathy.
B-cell depletion with rituximab may therefore be noninferior to treatment with cyclosporine for …

Importance The effect of glucocorticoids on major kidney outcomes and adverse events in IgA
nephropathy has been uncertain. Objective To evaluate the efficacy and adverse effects of …

Importance Although IgA nephropathy (IgAN) is the most common glomerulonephritis in the
world, there is no validated tool to predict disease progression. This limits patient-specific …

The Nephrotic Syndrome Study Network (NEPTUNE) is a North American multicenter
collaborative consortium established to develop a translational research infrastructure for …

Angiotensin converting enzyme (ACE) generates angiotensin II from angiotensin I, which
plays a critical role in the pathophysiology of diabetic nephropathy. However, ACE2 generates …

The Oxford Classification of IgA nephropathy (IgAN) includes the following four histologic
components: mesangial (M) and endocapillary (E) hypercellularity, segmental sclerosis (S) and …