A major challenge in human genetics is to devise a systematic strategy to integrate disease-associated
variants with diverse genomic and biological data sets to provide insight into …

Objective To evaluate the proposed relationship between persistent reduction of serum urate
into the subsaturating range and reduction in the frequency of acute gouty attacks. Methods …

Objectives: A large-scale postmarketing surveillance (PMS) study was carried out to determine
the safety profile of infliximab in Japanese patients with rheumatoid arthritis (RA). Methods…

Rheumatoid arthritis is a common autoimmune disease characterized by chronic inflammation.
We report a meta-analysis of genome-wide association studies (GWAS) in a Japanese …

Objective: To estimate the disease activity score (DAS)28-C-reactive protein (CRP) threshold
values that correspond to DAS28-erythrocyte sedimentation rate (ESR) values for remission…

Objective Patients with rheumatoid arthritis (RA) are at increased risk for herpes zoster (HZ) (ie,
shingles). The aim of this study was to determine whether treatment with tofacitinib …

Introduction Work disability is a major consequence of rheumatoid arthritis (RA), associated
not only with traditional disease activity variables, but also more significantly with …

RESULTS The distribution of SUA level The SUA levels at the baseline formed a nearly normal
distribution, slightly skewed to higher values, with a mean of 5.77 1.33 mg/dl (Fig. 1). For …

Rheumatoid arthritis is a common autoimmune disease with a complex genetic etiology.
Here, through a genome-wide association study of rheumatoid arthritis, we identified a …

Gout is a urate deposition disease caused by persistent hyperuricemia. Because gout
patients present with a variety of clinical symptoms, it is necessary to have a guideline for the …