Synthesis of phosphatidylinositol 4,5-bisphosphate [PI(4,5)P 2 ], a signaling phospholipid, is
primarily carried out by phosphatidylinositol 4-phosphate 5-kinase [PI(4)P5K], which has …

The freshwater cnidarian Hydra was first described in 1702 1 and has been the object of
study for 300 years. Experimental studies of Hydra between 1736 and 1744 culminated in the …

Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a potentially lethal
inherited arrhythmia syndrome in which drug therapy is often ineffective. We discovered that …

The field of optogenetics uses channelrhodopsins (ChRs) for light-induced neuronal activation.
However, optimized tools for cellular inhibition at moderate light levels are lacking. We …

Astaxanthin (1), a red-orange carotenoid pigment, is a powerful biological antioxidant that
occurs naturally in a wide variety of living organisms. The potent antioxidant property of 1 has …

Purpose: We performed a multicenter randomized controlled trial to determine whether
postoperative adjuvant chemotherapy improves outcome in patients with esophageal squamous …

Background— The metabolic syndrome consists of a cluster of atherosclerotic risk factors,
many of which also have been implicated in the genesis of atrial fibrillation (AF). However, the …

Brugada syndrome is a genetic disease associated with sudden cardiac death that is
characterized by ventricular fibrillation and right precordial ST segment elevation on ECG. Loss-of-…

… Akira Inoue, Takuji Suzuki, Tatsuro Fukuhara, Makoto Maemondo, Yuichiro Kimura,
Naoto Morikawa, Hiroshi Watanabe, Yasuo Saijo, and Toshihiro Nukiwa … Financial …

Brugada syndrome is a rare cardiac arrhythmia disorder, causally related to SCN5A
mutations in around 20% of cases 1 , 2 , 3 . Through a genome-wide association study of 312 …