Gefitinib versus cisplatin plus docetaxel in patients with non-small-cell lung cancer harbouring mutations of the epidermal growth factor receptor (WJTOG3405): an …

…, K Shibata, S Kudoh, E Shimizu, H Saito… - The lancet …, 2010 - thelancet.com
Background Patients with non-small-cell lung cancer harbouring mutations in the epidermal
growth factor receptor (EGFR) gene respond well to the EGFR-specific tyrosine kinase …

Effects of saffron extract and its constituent crocin on learning behaviour and long‐term potentiation

K Abe, H Saito - Phytotherapy Research, 2000 - Wiley Online Library
Crocus sativus L., commonly known as saffron, is used in folk medicine for various purposes.
Modern pharmacological studies have demonstrated that saffron extracts have antitumour …

Nonpolypoid neoplastic lesions of the colorectal mucosa

…, T Fujii, H Kashida, T Matsuda, M Mori, H Saito… - Gastrointestinal …, 2008 - Elsevier
The progress in our understanding of early events in the development of colonic neoplasia
is the result of 2 advances:(1) improved characterization of lesions detected at endoscopy …

The stability of O/W type emulsions as functions of temperature and the HLB of emulsifiers: the emulsification by PIT-method

K Shinoda, H Saito - Journal of colloid and interface science, 1969 - Elsevier
The properties of emulsions containing 3 wt% of polyoxyethylene nonylphenylether per
system were studied as functions of temperature, composition, and the hydrophile-lipophile …

3‐Hydroxykynurenine, an endogenous oxidative stress generator, causes neuronal cell death with apoptotic features and region selectivity

S Okuda, N Nishiyama, H Saito… - Journal of …, 1998 - Wiley Online Library
3‐Hydroxykynurenine (3‐HK) is a potential endogenous neurotoxin whose increased levels
have been described in several neurodegenerative disorders. Here, we characterized in …

[PDF][PDF] Randomized phase III trial of fluorouracil alone versus fluorouracil plus cisplatin versus uracil and tegafur plus mitomycin in patients with unresectable …

…, K Shirao, N Boku, I Hyodo, H Saito… - Journal of clinical …, 2003 - researchgate.net
Purpose: To compare fluorouracil (FU) alone with FU plus cisplatin (FP) and with uracil and
tegafur plus mitomycin (UFTM) for patients with advanced gastric cancer in a prospective, …

The relationship between chronic hypoxemia and activation of the tumor necrosis factor-α system in patients with chronic obstructive pulmonary disease

…, S ABE, S INOUE, T HINO, H SAITO… - American journal of …, 2000 - atsjournals.org
Although circulating tumor necrosis factor (TNF)- α levels have been found to be increased
in weight-losing patients with chronic obstructive pulmonary disease (COPD), the main …

Inhibition of GABAA synaptic responses by brain-derived neurotrophic factor (BDNF) in rat hippocampus

T Tanaka, H Saito, N Matsuki - Journal of Neuroscience, 1997 - Soc Neuroscience
Brain-derived neurotrophic factor (BDNF) is one of neurotrophins involved in the
development and maintenance of both the peripheral nervous system and CNS. Although the …

Hydrogen peroxide-mediated neuronal cell death induced by an endogenous neurotoxin, 3-hydroxykynurenine.

S Okuda, N Nishiyama, H Saito… - Proceedings of the …, 1996 - National Acad Sciences
3-Hydroxykynurenine (3-HK) is a tryptophan metabolite whose level in the brain is markedly
elevated under several pathological conditions, including Huntington disease and human …

Circulating leptin in patients with chronic obstructive pulmonary disease

…, H Nakamura, S Abe, T Hino, H Saito… - American journal of …, 1999 - atsjournals.org
Unexplained weight loss is common in patients with chronic obstructive pulmonary disease (COPD).
Since leptin, an obesity gene product, is known to play important roles in the control …