Oxygen metabolism has an important role in the pathogenesis of rheumatoid arthritis. Reactive
oxygen species (ROS) produced in the course of cellular oxidative phosphorylation, and …

Rheumatoid arthritis (RA) is characterized by the accumulation of CD4+ memory T cells in
the inflamed synovium. To address the mechanism, we analyzed chemokine receptor …

Statement of findings An inception cohort of 238 patients having peripheral joint synovitis of
less than 12 months duration was evaluated clinically and followed prospectively for 1 year …

Objective. Anticitrullinated protein antibodies (ACPA) are relatively specific for rheumatoid
arthritis (RA), and predate disease. The oral pathogen Porphyromonas gingivalis may play a …

… Additionally, this study is the first to demonstrate that this association is confined to ACPA-…
El-Gabalawy had full access to all of the data in the study and takes responsibility for the …

Recognition of the association between RA and PD on both a clinical and biologic level
may provide new opportunities for intervention that will modify the course of both of these …

… gingivalis PADI is able to citrullinate human fibrinogen and enolase and human peptide
citrullination is enhanced, but not completely dependent upon, the bacterial arginine gingipains …

Rheumatoid arthritis (RA) is a chronic autoimmune disease targeting multiple joints. The
synovium is the primary site of the inflammatory process, which if untreated leads to irreversible …

Objective. To determine the prevalence of anti-cyclic citrullinated peptide (anti-CCP) antibodies
in unaffected relatives of North American Native probands with rheumatoid arthritis (RA); …

Objective The autoimmune response in rheumatoid arthritis (RA) is marked by the presence
of anti–citrullinated protein antibodies (ACPAs). A notable feature of IgG ACPA is the …