Interleukin‐17–producing T cells are enriched in the joints of children with arthritis, but have a reciprocal relationship to regulatory T cell numbers
…, H Moncrieffe, KR Newton, H Varsani… - … : Official Journal of …, 2008 - Wiley Online Library
… Our preliminary data (Nistala K, Moncrieffe H: unpublished observations) suggest that there
is a correlation between the levels of IL-6 and the levels of IL-17 within the joint. Emerging …
is a correlation between the levels of IL-6 and the levels of IL-17 within the joint. Emerging …
CD25+CD4+ T cells compete with naive CD4+ T cells for IL-2 and exploit it for the induction of IL-10 production
T Barthlott, H Moncrieffe, M Veldhoen… - International …, 2005 - academic.oup.com
… We assessed mRNA for IL-2 at intervals up to 20 h after the onset of culture by real-time
PCR. Responder CD4 T cells were cultured with APC and anti-CD3 on their own or in the …
PCR. Responder CD4 T cells were cultured with APC and anti-CD3 on their own or in the …
The Toll-like receptor 4 agonist MRP8/14 protein complex is a sensitive indicator for disease activity and predicts relapses in systemic-onset juvenile idiopathic arthritis
…, S Hansmann, H Moncrieffe… - Annals of the …, 2012 - ard.bmj.com
Background Analysis of myeloid-related protein 8 and 14 complex (MRP8/14) serum
concentrations is a potential new tool to support the diagnosis of systemic-onset juvenile idiopathic …
concentrations is a potential new tool to support the diagnosis of systemic-onset juvenile idiopathic …
High expression of the ectonucleotidase CD39 on T cells from the inflamed site identifies two distinct populations, one regulatory and one memory T cell population
H Moncrieffe, K Nistala, Y Kamhieh, J Evans… - The Journal of …, 2010 - journals.aai.org
… Peripheral blood and synovial fluid samples were collected and processed within 2 h of
collection from patient. PBMCs and synovial fluid mononuclear cells (SFMCs) were isolated by …
collection from patient. PBMCs and synovial fluid mononuclear cells (SFMCs) were isolated by …
Modulation of dendritic cell function by naive and regulatory CD4+ T cells
M Veldhoen, H Moncrieffe, RJ Hocking… - The Journal of …, 2006 - journals.aai.org
… to 14 h in 1- to 2-h intervals, spanning the time frame during which stable T cell–DC interactions
precede the development of both tolerance and immunity in vivo (34). The results were …
precede the development of both tolerance and immunity in vivo (34). The results were …
A subgroup of juvenile idiopathic arthritis patients who respond well to methotrexate are identified by the serum biomarker MRP8/14 protein
H Moncrieffe, S Ursu, D Holzinger, F Patrick… - …, 2013 - academic.oup.com
Objectives. In JIA there is an unmet need for biomarkers with which to identify patients who
will respond well to MTX. The aim of this study was to define the prognostic value of baseline …
will respond well to MTX. The aim of this study was to define the prognostic value of baseline …
[HTML][HTML] Genetic regulation of serum IgA levels and susceptibility to common immune, infectious, kidney, and cardio-metabolic traits
…, SJ Hebbring, JB Harley, H Moncrieffe… - Nature …, 2022 - nature.com
Immunoglobulin A (IgA) mediates mucosal responses to food antigens and the intestinal
microbiome and is involved in susceptibility to mucosal pathogens, celiac disease, inflammatory …
microbiome and is involved in susceptibility to mucosal pathogens, celiac disease, inflammatory …
Th1 and Th17 cell subpopulations are enriched in the peripheral blood of patients with systemic juvenile idiopathic arthritis
…, A Pesenacker, K Nistala, H Moncrieffe… - …, 2012 - academic.oup.com
Objective. The role of the adaptive immune system has not been explored in detail compared
with the innate immune system in systemic JIA (sJIA) pathogenesis. The aim of this study …
with the innate immune system in systemic JIA (sJIA) pathogenesis. The aim of this study …
Genome‐Wide Association Meta‐Analysis reveals novel juvenile idiopathic arthritis susceptibility Loci
…, CA Wallace, CA Wise, H Moncrieffe… - Arthritis & …, 2017 - Wiley Online Library
Objective Juvenile idiopathic arthritis (JIA) is the most common childhood rheumatic disease
and has a strong genomic component. To date, JIA genetic association studies have had …
and has a strong genomic component. To date, JIA genetic association studies have had …
[HTML][HTML] Mothers' reports of the difficulties that their children experience in taking methotrexate for Juvenile Idiopathic Arthritis and how these impact on quality of life
…, L Kassoumeri, A Etheridge, H Moncrieffe… - Pediatric …, 2013 - Springer
Background Children who take methotrexate for juvenile idiopathic arthritis may experience
side effects, including nausea and vomiting, leading to anticipatory nausea in some children, …
side effects, including nausea and vomiting, leading to anticipatory nausea in some children, …