Immunology and clinical importance of antiphospholipid antibodies

HP McNeil, CN Chesterman, SA Krilis - Advances in immunology, 1991 - Elsevier
Publisher Summary There are two major methods for detecting Antiphospholipid (aPL)
antibodies. The first is based on a solid-phase immunoassay employing purified phospholipid …

S100 Calgranulins in inflammatory arthritis

C Perera, HP McNeil, CL Geczy - Immunology and cell biology, 2010 - Wiley Online Library
Calgranulins comprise three proteins, S100A8 (Calgranulin A), S100A9 (Calgranulin B) and
S100A12 (Calgranulin C) that are predominantly expressed by neutrophils, monocytes and …

Experiences and perspectives of adults living with systemic lupus erythematosus: thematic synthesis of qualitative studies

B Sutanto, D Singh‐Grewal, HP McNeil… - Arthritis care & …, 2013 - Wiley Online Library
Objective Systemic lupus erythematosus (SLE) is a chronic inflammatory autoimmune
disease that significantly impairs patients' quality of life and can be life threatening. This study …

Anti-phospholipid antibodies are directed against a complex antigen that includes a lipid-binding inhibitor of coagulation: beta 2-glycoprotein I (apolipoprotein H).

HP McNeil, RJ Simpson… - Proceedings of the …, 1990 - National Acad Sciences
Anti-phospholipid (aPL) antibodies that exhibit binding in cardiolipin (CL) ELISA can be
purified to greater than 95% purity by sequential phospholipid affinity and ion-exchange …

Safety and efficacy of vertebroplasty for acute painful osteoporotic fractures (VAPOUR): a multicentre, randomised, double-blind, placebo-controlled trial

…, P Gonski, TH Diamond, P Smerdely, HP McNeil… - The Lancet, 2016 - thelancet.com
Background We hypothesised that vertebroplasty provides effective analgesia for patients
with poorly controlled pain and osteoporotic spinal fractures of less than 6 weeks' duration. …

A phospholipid-β2-glycoprotein I complex is an antigen for anticardiolipin antibodies occurring in autoimmune disease but not with infection

JE Hunt, HP McNeil, GJ Morgan, RM Crameri… - Lupus, 1992 - journals.sagepub.com
Anticardiolipin antibodies (aCL) purified from patients with autoimmune disease have recently
been shown to interact with a phospholipid-binding plasma protein, β 2 -glycoprotein I (β …

Mast cells contribute to autoimmune inflammatory arthritis via their tryptase/heparin complexes

…, PA Nigrovic, J Crish, E Boilard, HP McNeil… - The Journal of …, 2009 - journals.aai.org
Although mast cells (MCs) often are abundant in the synovial tissues of patients with rheumatoid
arthritis, the contribution of MCs to joint inflammation and cartilage loss remains poorly …

An innovative outcomes-based medical education program built on adult learning principles

HP McNEIL, HP McNeil, CS Hughes, SM Toohey… - Medical …, 2006 - Taylor & Francis
… Patrick McNeil … PATRICK MCNEIL, MBBS PhD, is a former associate dean for medical
education … PATRICK MCNEIL, MBBS PhD, is a former associate dean for medical education and …

Mast cell responses in rheumatoid synovium. Association of the MCTC subset with matrix turnover and clinical progression

I Gotis‐Graham, HP McNeil - Arthritis & Rheumatism: Official …, 1997 - Wiley Online Library
Objective. To determine the distribution of mast cell subsets and their density in synovium
from normal subjects and from patients with osteoarthritis (OA) and rheumatoid arthritis (RA). …

Differential expression of secretory granule proteases in mouse mast cells exposed to interleukin 3 and c-kit ligand.

MF Gurish, N Ghildyal, HP McNeil, KF Austen… - The Journal of …, 1992 - rupress.org
It is now established that the subclasses of mast cells (MC) that reside in mucosal and
serosal environments can be distinguished from one another in terms of their expression of …