Bisphosphonates (BPs) and denosumab reduce the risk of spine and nonspine fractures.
Atypical femur fractures (AFFs) located in the subtrochanteric region and diaphysis of the femur …

Vertebral fracture is the most common complication of osteoporosis. It results in significant
mortality and morbidity, including prolonged and intractable pain in a minority of patients. …

Dual-energy X-ray absorptiometry (DXA) scanning was primarily developed for the diagnosis
of osteoporosis and was initially applied to studies of the clinically important sites of the …

… Genant HK, Sdrensen OH 1990 Effects of intermittent cyclical etidronate therapy on bone
mass and fracture rate in women with postmenopausal osteoporosis. N Engl J Med 322:1265-…

Background Previous studies have shown that alendronate can increase bone mineral
density (BMD) and prevent radiographically defined (morphometric) vertebral fractures. The …

Background Once-daily injections of parathyroid hormone or its amino-terminal fragments
increase bone formation and bone mass without causing hypercalcemia, but their effects on …

Women with low bone density in the radius or calcaneus are at increased risk of hip fracture.
To see whether bone density of the hip measured by dual X-ray absorptiometry is a better …

ContextRaloxifene hydrochloride, a selective estrogen receptor modulator, prevents bone
loss in postmenopausal women, but whether it reduces fracture risk in these women is not …

ContextRisedronate, a potent bisphosphonate, has been shown to be effective in the treatment
of Paget disease of bone and other metabolic bone diseases but, to our knowledge, it …

Background Osteoporotic structural damage and bone fragility result from reduced bone
formation and increased bone resorption. In a phase 2 clinical trial, strontium ranelate, an orally …