Comparison of the equilibrium response of articular cartilage in unconfined compression, confined compression and indentation

…, J Töyräs, J Rieppo, J Hirvonen, HJ Helminen… - Journal of …, 2002 - Elsevier
At mechanical equilibrium, articular cartilage is usually characterized as an isotropic elastic
material with no interstitial fluid flow. In this study, the equilibrium properties (Young's …

T2 relaxation reveals spatial collagen architecture in articular cartilage: A comparative quantitative MRI and polarized light microscopic study

…, MM Hyttinen, HJ Helminen… - … in Medicine: An …, 2001 - Wiley Online Library
It has been suggested that orientational changes in the collagen network of articular
cartilage account for the depthwise T 2 anisotropy of MRI through the magic angle effect. To …

Normal and pathological adaptations of articular cartilage to joint loading

…, JS Jurvelin, U Väätäinen, HJ Helminen - … Journal of Medicine …, 2000 - Wiley Online Library
Joints are functional units that transmit mechanical loads between contacting bones during
normal daily or specialized activities, eg, sports. All components of the joint, ie articular …

Hip muscle strength and muscle cross sectional area in men with and without hip osteoarthritis.

…, M Vesterinen, LH Niemitukia, HJ Helminen - The Journal of …, 2002 - jrheum.org
OBJECTIVE: To study the hip muscle strength and cross sectional area (CSA) in men with hip
osteoarthritis (OA) compared to age and sex matched healthy controls. METHODS: Based …

Moderate running exercise augments glycosaminoglycans and thickness of articular cartilage in the knee joint of young beagle dogs

…, AM Säämänen, HJ Helminen - Journal of …, 1988 - Wiley Online Library
The local influences of physical exercise on thickness and glycosaminoglycan (GAG) content
of canine articular cartilage were measured by microspectrophotometry of Safranin O‐ and …

Fibril reinforced poroelastic model predicts specifically mechanical behavior of normal, proteoglycan depleted and collagen degraded articular cartilage

…, J Töyräs, R Lappalainen, HJ Helminen… - Journal of …, 2003 - Elsevier
Degradation of collagen network and proteoglycan (PG) macromolecules are signs of articular
cartilage degeneration. These changes impair cartilage mechanical function. Effects of …

Effects of cyclic hydrostatic pressure on proteoglycan synthesis in cultured chondrocytes and articular cartilage explants

…, J Laakkonen, M Tammi, HJ Helminen - Archives of biochemistry …, 1993 - Elsevier
Primary chondrocyte cell cultures and explants of bovine articular cartilage were subjected
to cyclic hydrostatic pressure in a novel computer-controlled pressure chamber designed for …

Microspectrophotometric quantitation of glycosaminoglycans in articular cartilage sections stained with Safranin O

I Kiviranta, J Jurvelin, AM Säämänen, HJ Helminen - Histochemistry, 1985 - Springer
A new microspectrophotometric method was developed for quantitation of glycosaminoglycans
with Safranin O dye in articular cartilage matrix. From histological sections molar …

Quantitative MR microscopy of enzymatically degraded articular cartilage

…, J Silvennoinen, HJ Helminen… - … in Medicine: An …, 2000 - Wiley Online Library
Structural changes in bovine patellar articular cartilage, induced by component selective
enzymatic treatments, were investigated by measuring tissue T 2 relaxation at 9.4 T. This MRI …

Association between friction and wear in diarthrodial joints lacking lubricin

…, JR Torres, DK Rhee, HJ Helminen… - … : Official Journal of …, 2007 - Wiley Online Library
Objective The glycoprotein lubricin (encoded by the gene Prg4) is secreted by surface
chondrocytes and synovial cells, and has been shown to reduce friction in vitro. In contrast to man‐…