HMGB1 is a non-histone nuclear protein that can serve as an alarmin to drive the pathogenesis
of inflammatory and autoimmune disease. Although primarily located in the cell nucleus, …

… In support of this, he showed that peritoneal macrophages from Mrp1 −/− mice are
inefficient in HMGB1 secretion. In addition, HMGB1 secretion is associated with …

… Author links open overlay panel Ulf Andersson a , Helena Erlandsson Harris b … We thank
RA Harris for critically reading the manuscript. We also thank our co-workers Karin Palmblad …

Despite significant advances in intensive care therapy and antibiotics, severe sepsis accounts
for 9% of all deaths in the United States annually. The pathological sequelae of sepsis are …

High‐mobility group box chromosomal protein 1 (HMGB1) is a protein with both intranuclear
functions and extracellular cytokine‐like effects. In this report, we study possible candidate …

High mobility group box 1 (HMGB1), a ubiquitous DNA-binding protein, has been implicated
as a proinflammatory cytokine and late mediator of lethal endotoxemia. HMGB1 is released …

Innate immune receptors for pathogen- and damage-associated molecular patterns (PAMPs
and DAMPs) orchestrate inflammatory responses to infection and injury. Secreted by …

… Erlandsson Harris… Erlandsson Harris… The authors thank Associate Professor RA
Harris for linguistic advice and critical reading of the manuscript. …

… We are grateful to Ann-Britt Wikström, Lotta Aveberger, and Tomas Ernemar for excellent
technical assistance and to Associate Professor RA Harris for critically reading the manuscript. …

A prototypic mechanism for enhancement of inflammation by an endogenous molecule is
described. The nuclear protein HMGB1 has previously been demonstrated to act as an alarmin …