Recent progress in the development of molecular cancer therapeutics has revealed new
types of antitumor drugs, such as Herceptin, Gleevec, and Iressa, as potent therapeutics for …

Peripheral steroid hormones act on brain tissues through intracellular receptor-mediated
mechanisms to regulate several important brain neuronal functions. Therefore, the brain is …

Anaplastic lymphoma kinase (ALK) is a tyrosine kinase that is constitutively activated in certain
cancers, following gene alterations such as chromosomal translocation, amplification, or …

… 78–180 of human JAB) in kinase buffer (50 mM HEPES, pH 7.5, 50 mM NaCl, 5 mM MgCl
2 , 5 mM MnCl 2 and 0.1 mM Na 3 VO 4 ) in thepresence or absence of 0.2 mM ATP for 2 h at …

In addition, we introduce two other recent methods as future directions for estimating cortical
morphological changes: a multi-modal parcellation method using structural and functional …

… To elucidate the mechanism of high adsorption ability for C 2 H 2 molecules in complex 1,
we determined the structure of complex 1 with adsorbed C 2 H 2 molecules by the MEM (…

We identified in-frame fusion transcripts of KIF5B (the kinesin family 5B gene) and the RET
oncogene, which are present in 1–2% of lung adenocarcinomas (LADCs) from people from …

The Janus family of protein tyrosine kinases (JAKs) regulate cellular processes involved in
cell growth, differentiation and transformation through their association with cytokine receptors…

… HART consisted of a total dose of 576 Gy in 36 fractions delivered over 15 days using
three-times daily fractions with a 4-h interval between fractions and an 8-h interval between on-…

Background Although adjuvant chemotherapy with gemcitabine is standard care for resected
pancreatic cancer, S-1 has shown non-inferiority to gemcitabine for advanced disease. We …