Background Glucosamine and chondroitin sulfate are used to treat osteoarthritis. The
multicenter, double-blind, placebo- and celecoxib-controlled Glucosamine/chondroitin Arthritis …

Gout is a disorder that manifests as a spectrum of clinical and pathologic features built on a
foundation of an excess body burden of uric acid, manifested in part by hyperuricemia, which …

Background Febuxostat, a novel nonpurine selective inhibitor of xanthine oxidase, is a
potential alternative to allopurinol for patients with hyperuricemia and gout. Methods We …

Objective Existing criteria for the classification of gout have suboptimal sensitivity and/or
specificity, and were developed at a time when advanced imaging was not available. The …

In response to a request for proposal from the American College of Rheumatology (ACR), our
group was charged with developing nonpharmacologic and pharmacologic guidelines for …

Objective To compare the urate‐lowering efficacy and safety of febuxostat, allopurinol, and
placebo in a large group of subjects with hyperuricemia and gout, including persons with …

Objective To determine if hyperuricemia and gouty arthritis are independent risk factors for
acute myocardial infarction (MI) and, if so, whether they are independent of renal function, …

Introduction The purpose of this study was to compare urate-lowering (UL) efficacy and safety
of daily febuxostat and allopurinol in subjects with gout and serum urate (sUA) ≥ 8.0 mg/…

Objective. To determine whether sulfasalazine (SSZ) at a dosage of 2,000 mg/day is effective
for the treatment of active psoriatic arthritis (PsA) resistant to nonsteroidal antiinflammatory …

The relationship between serum uric acid (SUA) and cardiovascular disease has been
controversial. Here we review recent literature assessing whether hyperuricemia is an …