Hemophagocytic lymphohistiocytosis: an update on pathogenesis, diagnosis, and therapy
G Griffin, S Shenoi, GC Hughes - Best Practice & Research Clinical …, 2020 - Elsevier
Hemophagocytic lymphohistiocytosis (HLH) is a rare, life-threatening state of immune
hyperactivation that arises in the setting of genetic mutations and infectious, inflammatory, or …
hyperactivation that arises in the setting of genetic mutations and infectious, inflammatory, or …
Progesterone and autoimmune disease
GC Hughes - Autoimmunity reviews, 2012 - Elsevier
Sexual dimorphism in human immune systems is most apparent in the female
predominance of certain autoimmune diseases (ADs) like systemic lupus erythematosus (SLE). …
predominance of certain autoimmune diseases (ADs) like systemic lupus erythematosus (SLE). …
Modulation of autoimmune rheumatic diseases by oestrogen and progesterone
GC Hughes, D Choubey - Nature Reviews Rheumatology, 2014 - nature.com
Sexual dimorphism is evident in the risk and expression of several human autoimmune
diseases. Differences in disease manifestations observed between sexes are likely to involve …
diseases. Differences in disease manifestations observed between sexes are likely to involve …
Cutting edge: progesterone regulates IFN-α production by plasmacytoid dendritic cells
GC Hughes, S Thomas, C Li, MK Kaja… - The Journal of …, 2008 - journals.aai.org
Use of the progesterone (Pg) birth control depot medroxyprogesterone acetate (DMPA)
increases a woman’s risk for sexually transmitted infection with HIV or HSV-2 via unknown …
increases a woman’s risk for sexually transmitted infection with HIV or HSV-2 via unknown …
Neutrophil extracellular traps as a potential source of autoantigen in cocaine-associated autoimmunity
C Lood, GC Hughes - Rheumatology, 2017 - academic.oup.com
Objective. Exposure to illicit cocaine and its frequent adulterant, levamisole, is associated
with ANCAs targeting neutrophil elastase (NE), neutropenia and vasculitic/thrombotic skin …
with ANCAs targeting neutrophil elastase (NE), neutropenia and vasculitic/thrombotic skin …
The intracellular progesterone receptor regulates CD4+ T cells and T cell-dependent antibody responses
GC Hughes, EA Clark, AH Wong - Journal of leukocyte biology, 2013 - academic.oup.com
The intracellular progesterone receptor links the reproductive and immune systems via
regulation of CD4+ T cells. Pg has distinct immunomodulatory properties involved in poorly …
regulation of CD4+ T cells. Pg has distinct immunomodulatory properties involved in poorly …
Regulation of dendritic cells by female sex steroids: relevance to immunity and autoimmunity
GC Hughes, EA Clark - Autoimmunity, 2007 - Taylor & Francis
Dendritic cells (DCs) are critical mediators of adaptive immunity, tolerance and autoimmunity.
The human immune system exhibits sexual dimorphism, which is most evident in the …
The human immune system exhibits sexual dimorphism, which is most evident in the …
[HTML][HTML] Allergic aspects of IgG4-related disease: implications for pathogenesis and therapy
…, DM Schwartz, T Mustelin, GC Hughes - Frontiers in …, 2021 - frontiersin.org
IgG4-related disease (IgG4-RD) is a rare systemic fibroinflammatory disease frequently
associated with allergy. The pathogenesis of IgG4-RD is poorly understood, and effective …
associated with allergy. The pathogenesis of IgG4-RD is poorly understood, and effective …
Decrease in glomerulonephritis and Th1‐associated autoantibody production after progesterone treatment in NZB/NZW mice
GC Hughes, D Martin, K Zhang… - … : Official Journal of …, 2009 - Wiley Online Library
Objective While estrogen treatment exacerbates disease in models of systemic lupus
erythematosus (SLE), the effects of progesterone are unclear. This study was undertaken to assess …
erythematosus (SLE), the effects of progesterone are unclear. This study was undertaken to assess …
Management of oral and maxillofacial trauma during the first wave of the COVID-19 pandemic in the United Kingdom
…, K Herd, S Hislop, M Ho, D Houghton, C Hughes… - British journal of oral …, 2021 - Elsevier
We assess the effect of coronavirus disease 2019 (COVID-19) on UK oral and maxillofacial (OMF)
trauma services and patient treatment during the first wave of the pandemic. From 1 …
trauma services and patient treatment during the first wave of the pandemic. From 1 …