Plasma fibrinogen is a major determinant of platelet aggregation and blood viscosity. The
decrease in plasma fibrinogen by bezafibrate is associated with a decrease in the risk of …

Acquired hemophilia A (AHA), a rare bleeding disorder caused by neutralizing autoantibodies
against coagulation factor VIII (FVIII), occurs in both men and women without a previous …

Background: A mutation in the prothrombin gene (G→A 20210 ) has been associated with
higher plasma prothrombin levels and an increased tendency for venous thrombosis. …

… Di Minno is on leave of absence from lstituto di Clinica Medica II Policlinico, … Pike, Upjohn
Co., Kalamazoo, Michigan) was dissolved and stored as previously described by Di Minno and …

Cytochrome P450 CYP2C9 gene variants have been associated with hyperresponsiveness
to small doses of warfarin and a higher bleeding complication rate. The aim of this study was …

The aim of this study was to develop a simplified ultrasound scanning procedure and scoring
method, named Haemophilia Early Arthropathy Detection with UltraSound [HEAD-US], to …

Over the last 30 years, a growing body of evidence has documented the role of
hyperhomocysteinemia (HHcy) as an independent vascular risk factor. However, the mechanisms …

Activated protein C resistance (APCR) is responsible for most cases of familial thrombosis.
The factor V missense mutation Arg506>Gln (FV Leiden) has been recognized as the …

Background and Purpose— The mechanisms of ischemic stroke in young adults are poorly
understood. During the last years, several studies suggested a role for genetic factors …

We performed a case-controlled study to investigate whether the FV Leiden mutation and
the C>T 677 polymorphism of the 5,10 methylene tetrahydrofolate reductase (MTHFR) are …