Non-randomised studies of the effects of interventions are critical to many areas of healthcare
evaluation, but their results may be biased. It is therefore important to understand and …

The Newcastle-Ottawa Scale (NOS) for Assessing the Quality of Nonrandomized Studies in
Meta- Analysis Page 1 The Newcastle-Ottawa Scale (NOS) for Assessing the Quality of …

Background Our objective was to develop an instrument to assess the methodological
quality of systematic reviews, building upon previous tools, empirical evidence and expert …

ContextExercise is widely perceived to be beneficial for glycemic control and weight loss in
patients with type 2 diabetes. However, clinical trials on the effects of exercise in patients with …

We performed a meta-analysis of 14 genome-wide association studies of coronary artery
disease (CAD) comprising 22,233 individuals with CAD (cases) and 64,762 controls of …

Background Cardiac-resynchronization therapy (CRT) benefits patients with left ventricular
systolic dysfunction and a wide QRS complex. Most of these patients are candidates for an …

OBJECTIVE: Our purpose was to measure the agreement, reliability, construct validity, and
feasibility of a measurement tool to assess systematic reviews (AMSTAR). STUDY DESIGN …

Background There is much controversy about the use of computed tomography (CT) for
patients with minor head injury. We aimed to develop a highly sensitive clinical decision rule for …

Background: Previous trials have evaluated the effects of aerobic training alone and of resistance
training alone on glycemic control in type 2 diabetes, as assessed by hemoglobin A 1c …

Coronary artery disease (CAD) is the commonest cause of death. Here, we report an
association analysis in 63,746 CAD cases and 130,681 controls identifying 15 loci reaching …