Rheumatoid arthritis is the most common inflammatory arthritis and is a major cause of
disability. It existed in early Native American populations several thousand years ago but might …

NF-κB in defense and disease serine residues. Phosphorylated IκBα is then ubiquitinated,
which targets it for degradation by the 26S proteasome (13), thereby releasing NF-κB dimers …

Rheumatoid arthritis (RA) is the most common inflammatory arthropathy. The majority of
evidence, derived from genetics, tissue analyses, models, and clinical studies, points to an …

To define the cell populations that drive joint inflammation in rheumatoid arthritis (RA), we
applied single-cell RNA sequencing (scRNA-seq), mass cytometry, bulk RNA sequencing (…

Granulocytes and monocytes/macrophages of the myeloid lineage are the chief cellular
agents of innate immunity. Here, we have examined the inflammatory response in mice with …

Rheumatoid arthritis (RA) remains a significant unmet medical need despite significant
therapeutic advances. The pathogenesis of RA is complex and includes many cell types, …

Mitogen-activated protein kinase (MAPK) cascades are involved in inflammation and tissue
destruction in rheumatoid arthritis (RA). In particular, c-Jun N-terminal kinase (JNK) is highly …

Rheumatoid Arthritis Rheumatoid arthritis is a chronic, systemic autoimmune disease
manifested primarily as inflammatory arthritis, typically involving the small joints of the hands …

Rheumatoid arthritis (RA) is characterized by hyperplastic synovial pannus tissue, which
mediates destruction of cartilage and bone. Fibroblast-like synoviocytes (FLS) are a key …

Rheumatoid arthritis (RA) is a chronic immune-mediated disease that primarily affects the
synovium of diarthrodial joints. During the course of RA, the synovium transforms into a …