Metformin is widely used for the treatment of type 2 diabetes mellitus. It is a biguanide
developed from galegine, a guanidine derivative found in Galega officinalis (French lilac). …

The kinetics of a drug eliminated by first-order processes in a perfusion-limited isolated perfused
organ system are examined. In this model, the mean clearance, determined by dividing …

Paracetamol (acetaminophen) is generally considered to be a weak inhibitor of the synthesis
of prostaglandins (PGs). However, the in vivo effects of paracetamol are similar to those of …

Paracetamol is used worldwide for its analgesic and antipyretic actions. It has a spectrum of
action similar to that of NSAIDs and resembles particularly the COX-2 selective inhibitors. …

Benzbromarone, a potent uricosuric drug, was introduced in the 1970s and was viewed as
having few associated serious adverse reactions. It was registered in about 20 countries …

… Richard O Day professor of clinical pharmacology1 2, Garry G Graham professorial
visiting fellow1 2 … Her present drug treatment is paracetamol (4 g daily) and metformin. …

Antibacterial properties of secreted phospholipases A 2 (PLA 2 ) have emerged gradually.
Group (G) IIA PLA 2 is the most potent among mammalian secreted (s) PLA 2 s against Gram-…

Allopurinol is the drug most widely used to lower the blood concentrations of urate and,
therefore, to decrease the number of repeated attacks of gout. Allopurinol is rapidly and …

The excellent tolerability of therapeutic doses of paracetamol (acetaminophen) is a major
factor in the very wide use of the drug. The major problem in the use of paracetamol is its …

Background Allopurinol is the primary therapy for the management of chronic gout. Utilization
of allopurinol has increased in tandem with the growing prevalence of gout globally. This …