User profiles for GARRY G. GRAHAM
Graham GarryProfessor of Pharmacology, University of New South Wales Verified email at unsw.edu.au Cited by 11130 |
Clinical pharmacokinetics of metformin
Metformin is widely used for the treatment of type 2 diabetes mellitus. It is a biguanide
developed from galegine, a guanidine derivative found in Galega officinalis (French lilac). …
developed from galegine, a guanidine derivative found in Galega officinalis (French lilac). …
Clearance concepts in pharmacokinetics
The kinetics of a drug eliminated by first-order processes in a perfusion-limited isolated perfused
organ system are examined. In this model, the mean clearance, determined by dividing …
organ system are examined. In this model, the mean clearance, determined by dividing …
Mechanism of action of paracetamol
Paracetamol (acetaminophen) is generally considered to be a weak inhibitor of the synthesis
of prostaglandins (PGs). However, the in vivo effects of paracetamol are similar to those of …
of prostaglandins (PGs). However, the in vivo effects of paracetamol are similar to those of …
The modern pharmacology of paracetamol: therapeutic actions, mechanism of action, metabolism, toxicity and recent pharmacological findings
Paracetamol is used worldwide for its analgesic and antipyretic actions. It has a spectrum of
action similar to that of NSAIDs and resembles particularly the COX-2 selective inhibitors. …
action similar to that of NSAIDs and resembles particularly the COX-2 selective inhibitors. …
A benefit-risk assessment of benzbromarone in the treatment of gout: was its withdrawal from the market in the best interest of patients?
Benzbromarone, a potent uricosuric drug, was introduced in the 1970s and was viewed as
having few associated serious adverse reactions. It was registered in about 20 countries …
having few associated serious adverse reactions. It was registered in about 20 countries …
Non-steroidal anti-inflammatory drugs (NSAIDs)
… Richard O Day professor of clinical pharmacology1 2, Garry G Graham professorial
visiting fellow1 2 … Her present drug treatment is paracetamol (4 g daily) and metformin. …
visiting fellow1 2 … Her present drug treatment is paracetamol (4 g daily) and metformin. …
Antibacterial actions of secreted phospholipases A2. Review
Antibacterial properties of secreted phospholipases A 2 (PLA 2 ) have emerged gradually.
Group (G) IIA PLA 2 is the most potent among mammalian secreted (s) PLA 2 s against Gram-…
Group (G) IIA PLA 2 is the most potent among mammalian secreted (s) PLA 2 s against Gram-…
Clinical pharmacokinetics and pharmacodynamics of allopurinol and oxypurinol
Allopurinol is the drug most widely used to lower the blood concentrations of urate and,
therefore, to decrease the number of repeated attacks of gout. Allopurinol is rapidly and …
therefore, to decrease the number of repeated attacks of gout. Allopurinol is rapidly and …
Tolerability of paracetamol
The excellent tolerability of therapeutic doses of paracetamol (acetaminophen) is a major
factor in the very wide use of the drug. The major problem in the use of paracetamol is its …
factor in the very wide use of the drug. The major problem in the use of paracetamol is its …
Allopurinol hypersensitivity: a systematic review of all published cases, 1950–2012
…, MWH Smith, N Wang, DM Roberts, GG Graham… - Drug safety, 2013 - Springer
Background Allopurinol is the primary therapy for the management of chronic gout. Utilization
of allopurinol has increased in tandem with the growing prevalence of gout globally. This …
of allopurinol has increased in tandem with the growing prevalence of gout globally. This …