BACKGROUND Osteoarthritis is the single most common cause of disability in older adults,
and most patients with the condition will be managed in the community and primary care. …

Objective To develop evidence-based recommendations for the diagnosis of knee osteoarthritis
(OA). Methods The multidisciplinary guideline development group, representing 12 …

Objectives. Exercise is an effective and commonly prescribed intervention for lower limb
osteoarthritis (OA). Many unanswered questions remain, however, concerning the practical …

This “Year in review” presents a selection of research themes and individual studies from
the clinical osteoarthritis (OA) field (epidemiology and therapy) and includes noteworthy …

Open Targets Genetics ( https://genetics.opentargets.org ) is an open-access integrative
resource that aggregates human GWAS and functional genomics data including gene …

The Open Targets Platform ( https://www.targetvalidation.org/ ) provides users with a queryable
knowledgebase and user interface to aid systematic target identification and prioritisation …

Although pain is experienced at all ages, there is uncertainty about the pattern of its
occurrence in older people. We have investigated the prevalence of three aspects of self-reported …

The Open Targets Platform integrates evidence from genetics, genomics, transcriptomics,
drugs, animal models and scientific literature to score and rank target-disease associations for …

Objective Studies of previous cohorts have demonstrated an association between a status
of overweight/obesity and the presence of knee and hand osteoarthritis (OA). However, no …

… , Joanne L Jordan research information manager1, Krysia S Dziedzic Arthritis Research UK
professor of musculoskeletal therapies1, Emma L Healey research fellow1, George M Peat …