Chronic immune stimulation correlates with reduced phenylalanine turnover

G Neurauter, K Schrocksnadel… - Current drug …, 2008 - ingentaconnect.com
Neurospychiatric symptoms like mood changes and depression are common in patients with
chronic inflammatory disorders such as infections, autoimmune diseases or cancer. The …

Interferon-γ-induced conversion of tryptophan: immunologic and neuropsychiatric aspects

B Wirleitner, G Neurauter… - Current medicinal …, 2003 - ingentaconnect.com
Tryptophan is an essential amino acid and the least abundant constituent of proteins. In
parallel it represents a source for two important biochemical pathways: the generation of …

Interferon-alpha–induced changes in tryptophan metabolism: relationship to depression and paroxetine treatment

L Capuron, G Neurauter, DL Musselman, DH Lawson… - Biological …, 2003 - Elsevier
… Blood was immediately chilled on ice and subsequently centrifuged at 1000 g for 10 min
at 4C. Plasma was then separated and stored at −80C until assayed. Free TRP and KYN …

Immune activation and degradation of tryptophan in coronary heart disease

B Wirleitner, V Rudzite, G Neurauter… - European journal of …, 2003 - Wiley Online Library
Background Inflammation and immune activation appear to be important in the pathogenesis
of coronary heart disease (CHD). Cytokine interferon‐γ, which is released during cell‐…

More rapid method for simultaneous measurement of tryptophan and kynurenine by HPLC

A Laich, G Neurauter, B Widner, D Fuchs - Clinical chemistry, 2002 - academic.oup.com
… Samples were centrifuged at 12 000 g for 6 min at room temperature to precipitate and
separate the protein. Supernatants (180 μL) were transferred into microsampling vials placed in …

Increasing production of homocysteine and neopterin and degradation of tryptophan with older age

B Frick, K Schroecksnadel, G Neurauter, F Leblhuber… - Clinical …, 2004 - Elsevier
Objectives: Aging is associated with an increased frequency of abnormal immune system
function, which may cause infections, autoimmune diseases, and cardiovascular or …

Serum phenylalanine in patients post trauma and with sepsis correlate to neopterin concentrations

M Ploder, G Neurauter, A Spittler, K Schroecksnadel… - Amino acids, 2008 - Springer
Increased blood concentrations of phenylalanine in patients with trauma and sepsis are
common but unexplained. We examined the potential relationship between serum …

Serum phenylalanine concentrations in patients with ovarian carcinoma correlate with concentrations of immune activation markers and of isoprostane-8

G Neurauter, AV Grahmann, M Klieber, A Zeimet… - Cancer Letters, 2008 - Elsevier
Increased blood concentrations of essential amino acid phenylalanine are common in patients
with HIV infection, in trauma and sepsis and in patients with cancer. The reason for this …

Increased degradation of tryptophan in blood of patients with rheumatoid arthritis.

…, S Kaser, M Ledochowski, G Neurauter… - The Journal of …, 2003 - jrheum.org
… (IDO) by interferon (IFN)-g leads to enhanced tryptophan conversion to kynurenine. In …
CONCLUSIONS: The data point to a role of immune activation and Th1-type cytokine INF-g

Effective antiretroviral therapy reduces degradation of tryptophan in patients with HIV-1 infection

R Zangerle, B Widner, G Quirchmair, G Neurauter… - Clinical …, 2002 - Elsevier
Antiretroviral therapy (ART) has a significant impact on HIV-1 RNA levels, the CD4 cell count,
and immune activation. We examined whether these changes are associated with a …