Newly identified antiatherosclerotic activity of methotrexate and adalimumab: complementary effects on lipoprotein function and macrophage cholesterol metabolism

…, F Zimetti, E Favari, G Hjeltnes… - Arthritis & …, 2015 - Wiley Online Library
Objective Rheumatoid arthritis (RA) is associated with accelerated atherosclerosis. The
reduction in cardiovascular risk that is induced by methotrexate (MTX) and anti–tumor necrosis …

Anti-CCP and RF IgM: predictors of impaired endothelial function in rheumatoid arthritis patients

G Hjeltnes, I Hollan, Ø Førre, A Wiik… - Scandinavian journal …, 2011 - Taylor & Francis
Objective: To determine whether the presence of anti-cyclic citrullinated peptide (anti-CCP)
antibodies and rheumatoid factor immunoglobulin M (RF IgM) is associated with endothelial …

[HTML][HTML] Methotrexate and anti-tumor necrosis factor treatment improves endothelial function in patients with inflammatory arthritis

…, T Lyberg, N Ronda, K Mikkelsen, G Hjeltnes… - Arthritis research & …, 2017 - Springer
Background Inflammatory arthritis (IA), including rheumatoid arthritis (RA), ankylosing spondylitis
(AS) and psoriatic arthritis (PsA), leads to increased cardiovascular disease occurrence …

[PDF][PDF] Serum levels of lipoprotein (a) and E-selectin are reduced in rheumatoid arthritis patients treated with methotrexate or methotrexate in combination with TNF …

G Hjeltnes, I Hollan, O Førre, A Wiik… - Clin Exp …, 2013 - clinexprheumatol.org
Objective To examine the effect of methotrexate (MTX) with or without tumour necrosis factor
alpha (TNF-α)-inhibitors on serum lipoprotein (a)(s-Lp (a)), and to explore a possible …

[HTML][HTML] Antirheumatic treatment is associated with reduced serum Syndecan-1 in Rheumatoid Arthritis

G Deyab, TM Reine, TT Vuong, T Jenssen, G Hjeltnes… - PLoS …, 2021 - journals.plos.org
The endothelial glycocalyx (EG) is essential for proper function of the endothelium and for
vascular integrity, but its role in premature atherogenesis in rheumatoid arthritis (RA) has not …

[HTML][HTML] Tumor necrosis factor inhibitors are associated with reduced complement activation in spondylarthropathies: An observational study

…, G Deyab, M Wang Fagerland, T Lyberg, G Hjeltnes… - PLoS …, 2019 - journals.plos.org
Background The complement system is involved in pathogenesis of cardiovascular disease,
and might play a role in accelerated atherogenesis in spondylarthropathies (SpA). Hence, …

[HTML][HTML] Anti-rheumatic treatment is not associated with reduction of pentraxin 3 in rheumatoid arthritis, psoriatic arthritis and ankylosing spondylitis

…, T Lyberg, B Bottazzi, PL Meroni, R Leone, G Hjeltnes… - PloS one, 2017 - journals.plos.org
Background Pentraxin 3 is proposed to be a marker of inflammation and cardiovascular risk,
but its role in inflammatory rheumatic diseases (IRDs) is still uncertain. Therefore, we …

[HTML][HTML] Antirheumatic therapy is associated with reduced complement activation in rheumatoid arthritis

…, TE Mollnes, I Hollan, MW Feinberg, G Hjeltnes… - PLoS …, 2022 - journals.plos.org
Background The complement system plays an important role in pathophysiology of
cardiovascular disease (CVD), and might be involved in accelerated atherogenesis in rheumatoid …

[HTML][HTML] Antirheumatic therapy is not associated with changes in circulating N-terminal pro-brain natriuretic peptide levels in patients with autoimmune arthritis

THP Nguyen, MW Fagerland, G Deyab, G Hjeltnes… - PLoS …, 2021 - journals.plos.org
Background Patients with autoimmune arthritis (AA) are at increased risk for impaired
cardiac function and heart failure. This may be partly due to the effect of inflammation in heart …

[HTML][HTML] Effects of antirheumatic treatment on cell cholesterol efflux and loading capacity of serum lipoproteins in spondylarthropathies

…, MW Fagerland, S Agewall, G Hjeltnes… - Journal of Clinical …, 2022 - mdpi.com
Spondyloarthropathies (SpA) are associated with increased cardiovascular risk. Among
possible mechanisms is the dysfunction of serum lipoproteins in regulating cell cholesterol …