User profiles for G. CAMBRIDGE

Graeme Cambridge

University of Toronto
Verified email at chem.utoronto.ca
Cited by 1692

B-cell targeting in rheumatoid arthritis and other autoimmune diseases

JCW Edwards, G Cambridge - Nature Reviews Immunology, 2006 - nature.com
… In patients with autoimmune disease, approximately 2–3 g of rituximab in total is given as a
series … Cambridge, G. et al. Serological changes following B lymphocyte depletion therapy for …

Sustained improvement in rheumatoid arthritis following a protocol designed to deplete B lymphocytes

JCW Edwards, G Cambridge - Rheumatology, 2001 - academic.oup.com
Objectives. An open study of B‐lymphocyte depletion was undertaken in rheumatoid
arthritis (RA) patients to test the hypothesis that B lymphocytes may be essential to disease …

An open study of B lymphocyte depletion in systemic lupus erythematosus

MJ Leandro, JC Edwards, G Cambridge… - Arthritis & …, 2002 - Wiley Online Library
Objective To gain preliminary evidence for the safety and efficacy of B lymphocyte depletion
therapy in refractory systemic lupus erythematosus (SLE). Methods Six female patients with …

Reconstitution of peripheral blood B cells after depletion with rituximab in patients with rheumatoid arthritis

MJ Leandro, G Cambridge… - … : Official Journal of …, 2006 - Wiley Online Library
Objective To study the quantitative and phenotypic reconstitution of peripheral blood B cells
and its relationship to the dynamics of clinical response in patients with rheumatoid arthritis (…

Serologic changes following B lymphocyte depletion therapy for rheumatoid arthritis

G Cambridge, MJ Leandro… - … : Official Journal of …, 2003 - Wiley Online Library
Serologic changes following B lymphocyte depletion therapy for rheumatoid arthritis -
Cambridge - 2003 - Arthritis & Rheumatism - Wiley Online Library … Geraldine Cambridge PhD …

B-cell depletion in the treatment of patients with systemic lupus erythematosus: a longitudinal analysis of 24 patients

MJ Leandro, G Cambridge, JC Edwards… - …, 2005 - academic.oup.com
Objectives. To assess the clinical and basic serological consequences of B-cell depletion
with rituximab in the treatment of patients with systemic lupus erythematosus (SLE) who have …

Clinical outcome in 22 patients with rheumatoid arthritis treated with B lymphocyte depletion

…, JCW Edwards, G Cambridge - Annals of the rheumatic …, 2002 - ard.bmj.com
Objectives: To obtain evidence for dose response and to extend evidence of safety and
efficacy for B lymphocyte depletion in rheumatoid arthritis. Methods: Twenty two patients with …

Complex and hierarchical micelle architectures from diblock copolymers using living, crystallization-driven polymerizations

T Gädt, NS Ieong, G Cambridge, MA Winnik… - Nature materials, 2009 - nature.com
… 1g), which indicates that the platelet edges are not densely covered with a PI brush layer
but are available for epitaxial growth. The selective nature of the growth from the faces at the …

A retrospective seven‐year analysis of the use of B cell depletion therapy in systemic lupus erythematosus at university college london hospital: the first fifty patients

TYT Lu, KP Ng, G Cambridge… - Arthritis Care & …, 2009 - Wiley Online Library
… A previous study by Cambridge et al (14) showed that antipneumococcal responses are
preserved after 1 cycle of BCDT in patients with SLE for at least 1 year. Two other adverse …

Circulating levels of B lymphocyte stimulator in patients with rheumatoid arthritis following rituximab treatment: relationships with B cell depletion, circulating antibodies …

G Cambridge, W Stohl, MJ Leandro… - Arthritis & …, 2006 - Wiley Online Library
… Pretreatment serum anti-CCP antibody levels were elevated (>200 IU/ml) in 7 of the 10
patients tested (Figure 1G). Although they visually paralleled the changes in RF levels, the …