Purpose: We report a male child who presented at 15 months with perianal abscesses and
proctitis, progressing to transmural pancolitis with colocutaneous fistulae, consistent with a …

783 Letter of IgG1, which antagonizes soluble TNF-α. Etanercept was given with MTX in our
cases, based on favorable experience using combined therapy with these drugs in juvenile …

Background No consensus evidence-based guidelines for the routine laboratory monitoring
of children with JIA receiving non-steroidal anti-inflammatory drugs (NSAIDs) exist. The …

It has been proposed that two recent guidelines, both endorsed by the ACMG, are in tension
with each other because they result in opposing outcomes with respect to genetic testing of …

Background Milestones-based end-of-rotation assessments by faculty may be used to help
Clinical Competency Committees (CCCs) assign summative resident sub-competency …

Objective: X-linked inhibitor of apoptosis (xIAP) deficiency is a primary immune deficiency
disorder associated with hemophagocytic lymphohistiocytosis. About 17% of xIAP-deficient …

Next-generation sequencing (NGS) technologies have dramatically dropped the cost of
whole genome or exome (the 2% of the genome represented by coding regions) sequencing. …

The generation of H 2 during serpentinization of ultramafic oceanic crust along Earth's mid-ocean
ridges provides a key energy source for the deep biosphere and has important …

Topographic maps ofthe Burroughs Glacier ice surface and the surrounding land surface from
1948 to 1990 were used to generate subglacial hydraulic head maps and compare esker …

Evolving interactions between predators and prey constitute one of the major adaptive
influences on marine animals during the Paleozoic. Crinoids and fish constitute a predator–prey …