Introduction: The P2X7 receptor (P2X7R) has an important role in inflammation and immunity,
but until recently, clinical application has been limited by a lack of specific antagonists. …

Monocyte chemoattractant protein-1 (MCP-1/CCL2) has a critical role in the development of
various renal diseases. Data from disease specific experimental animal models and clinical …

The inflammasome is a large, multiprotein complex that drives proinflammatory cytokine
production in response to infection and tissue injury. Pattern recognition receptors that are either …

Hepcidin is a critical inhibitor of iron export from macrophages, enterocytes, and hepatocytes.
Given that it is filtered and degraded by the kidney, its elevated levels in renal failure have …

Expression of hepcidin, the key hormone governing iron transport, is reduced by anemia in
a manner which appears dependent on increased bone marrow activity. The temporal …

… Increased urinary MCP-1 is found in patients with active renal vasculitis and persistence
of this increase is associated with progression to end-stage renal failure (abstract; Tam, J Am …

The anti-inflammatory, antifibrotic, and antiproteinuric properties of vitamin D have been
defined in studies using active vitamin D analogs. In this prospective observational study we …

… Anti-TNF-α monoclonal antibody or saline was given intraperitoneally three times per week
in four protocols: experiment 1, days 0 to 7; experiment 2, days 0 to 14 and days 4 to 14; …

Background Bariatric surgery improves arterial hypertension and renal function; however,
the underlying mechanisms and effect of different surgical procedures are unknown. In the …

Profibrotic growth factors and inflammatory chemokines have been implicated in the
pathogenesis of diabetic nephropathy (DN). However, measurement of urinary monocyte …