Objective Osteoarthritis (OA) of the knee causes significant morbidity and current medical
treatment is limited to symptom relief, while therapies able to slow structural damage remain …

Background Knee osteoarthritis (OA) is a major cause of pain and functional limitation in
older adults, yet longer-term studies of medical treatment of OA are limited. Objective To …

Agreement on response criteria in rheumatoid arthritis (RA) has allowed better standardization
and interpretation of clinical trial reports. With recent advances in therapy, the proportion …

PURPOSE: Randomized controlled trials (RCTs) have demonstrated the efficacy of biologic
agents in the treatment of rheumatic diseases. However, results from RCTs may not be …

Objective Since the introduction of the Medicare Prescription Drug Improvement and
Modernization Act and its associated demonstration project, coverage of selected biologic drugs …

Objective. The superiority of true drug treatment over placebo in reducing symptoms of
fibromyalgia syndrome (FMS) is small and bought by relevant rates of drop-outs due to adverse …

Background Ulcerative colitis (UC) is a chronic relapsing inflammatory bowel disease.
Psychological factors such as depression and stress are under debate to contribute to the risk of …

Objective. This study aims to provide robust estimates of EQ-5D as a function of the HAQ and
pain in patients with RA. Method. Repeated observations were made of patients diagnosed …

OBJECTIVE: To determine whether nontraditional risk factors increase the accuracy of
predicting the presence of carotid artery plaque based on traditional cardiovascular risk factors …

Background: Analysts frequently estimate health state utility values from other outcomes.
Utility values like EQ-5D have characteristics that make standard statistical methods …