Background Somatic mutations of the k-RAS oncogene have been assessed as a
mechanism of de-novo resistance to epidermal growth factor receptor (EGFR) tyrosine-kinase …

Learning Objectives After completing this course, the reader will be able to: Summarize the
main characteristics and findings of randomized controlled trials evaluating trastuzumab for …

Purpose: The aim of this systematic review and meta-analysis was to characterize common
EGFR molecular aberrations as potential predictive biomarkers for response to monotherapy …

Sub-valvular apparatus preservation after mitral valve replacement is not a new concept, yet
to date there has been no quantification of its clinical effectiveness as a procedure and no …

Background: Psoriatic arthritis may progress to joint damage. Joint damage may be assessed
clinically, by identifying deformed, fused, or flail joints, or radiologically, by recording …

Most statistical methods for censored survival data assume there is no dependence between
the lifetime and censoring mechanisms, an assumption which is often doubtful in practice. …

Background: Tumour necrosis factor α (TNFα) is a cytokine of critical importance in psoriatic
arthritis. Objectives: (1) To examine the association between TNFα promoter gene …

OBJECTIVE: Reported associations between HLA alleles and both susceptibility to and features
of scleroderma have been conflicting. Our objective was (1) to determine the role of HLA …

Objective. To determine the association between folate pathway gene polymorphisms and
the effectiveness, toxicity, and drug survival of methotrexate (MTX) in psoriatic arthritis (PsA). …

When competing risks data arise, information on the actual cause of failure for some subjects
might be missing. Therefore, a cause‐specific proportional hazards model together with …