Background Histone deimination regulates gene function and contributes to antimicrobial
response, allowing the formation of neutrophil extracellular traps (NETs). Deiminated proteins …

Neutrophil extracellular traps (NET) formation is part of the neutrophil response to infections,
but excessive or inappropriate NETosis may trigger the production of autoantibodies and …

Deimination is catalyzed by a family of calcium binding enzymes, called peptidylarginine
deiminases (PADs). Among these, the PAD4 isoform has been more extensively studied for its …

The characterization of antibodies that cause autoimmune GN is essential for clarifying
disease pathogenesis, defining biomarkers, and developing novel therapies. The detection of …

Objectives Rheumatoid arthritis (RA) is characterised by breach of self-tolerance towards
citrullinated antigens with generation of anti-citrullinated peptide/proteins antibodies (ACPA). …

The role of the cytokines and receptors of the IL-1 family in inflammation is well known.
Several cytokines of the family have a powerful inflammatory activity, with IL-1β being the best-…

Objective To test the hypothesis that deimination of viral sequences containing Arg–Gly repeats
could generate epitopes recognized by anti–citrullinated protein antibodies (ACPAs) that …

In neutrophils (but also in eosinophils and in mast cells), different inflammatory stimuli
induce histone deimination, chromatin decondensation, and NET formation. These web-like …

Objective. Neutrophil extracellular traps (NET) expose modified antigens for autoantibodies
in vasculitis. Little is known about levels and removal pathways of NET in systemic lupus …

Objective To analyze the presence and specificity of anti-alpha-enolase antibodies in
various systemic autoimmune diseases. Methods Sera from patients with systemic lupus …