Background Reliable and timely information on the leading causes of death in populations,
and how these are changing, is a crucial input into health policy debates. In the Global …

Gout is a disorder that manifests as a spectrum of clinical and pathologic features built on a
foundation of an excess body burden of uric acid, manifested in part by hyperuricemia, which …

Background Measurement of the global burden of disease with disability-adjusted life-years
(DALYs) requires disability weights that quantify health losses for all non-fatal …

Objective Existing criteria for the classification of gout have suboptimal sensitivity and/or
specificity, and were developed at a time when advanced imaging was not available. The …

In response to a request for proposal from the American College of Rheumatology (ACR), our
group was charged with developing nonpharmacologic and pharmacologic guidelines for …

Objective The optimal serum urate levels necessary for elimination of tissue deposits of
monosodium urate in patients with chronic gout is controversial. This observational, prospective …

Substantial evidence suggests that chronic hyperuricemia is an independent risk factor for
hypertension, metabolic syndrome, chronic kidney disease (CKD) and cardiovascular …

Gout is the most common inflammatory arthritis and one in which pathogenesis and risk
factors are best understood. One of the treatment objectives in current guidelines is ‘cure’. …

Hyperuricemia results from an imbalance between the rates of production and excretion of
uric acid. Longstanding hyperuricemia can lead to gout, which is characterized by the …

Although gout is the most common inflammatory arthritis, it is still frequently misdiagnosed.
New data on imaging and clinical diagnosis have become available since the first EULAR …