Anti-mitochondrial antibodies (AMA) are directed against the E2 subunits of the 2-oxo acid
dehydrogenase complexes (PDC-E2) and are the typical biomarkers of primary biliary …

Simple Summary Incidence of biliary tract cancer is increasing, and patients are frequently
diagnosed with unresectable or metastatic disease, when therapeutic options are limited. Due …

… First of all, the F:M ratio of 2:1 observed for antimitochondrial antibody (AMA) positivity among
the general population is highly different from F:M ratios observed in PBC itself, and this is …

Osteogenesis imperfecta (OI) is a heritable disease of connective tissue, characterized by
increased bone fragility. Bisphosphonates currently seems to be the most promising therapy, …

Background & aims Obeticholic acid (OCA) is the second-line treatment approved for
patients with primary biliary cholangitis (PBC) and an inadequate response or intolerance to …

Introduction Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) has infected
189 000 people in Italy, with more than 25 000 deaths. Several predictive factors of mortality …

Osteogenesis imperfecta (OI) is a heterologous group of rare inherited bone disorders
resulting from defect in collagen synthesis or function. In previous studies, bone turnover has …

The purpose of this study was to evaluate the efficacy and safety of the Moderna-1273
mRNA vaccine for SARS-CoV-2 in patients with immune-mediated diseases under different …

Ursodeoxycholic acid (UDCA) was demonstrated to reduce susceptibility to SARS-CoV-2
infection in vitro and improve infection course in chronic liver diseases. However, real-life …

Introduction Primary biliary cholangitis (PBC) is an autoimmune liver disease involving the
small intrahepatic bile ducts; when untreated or undertreated, it may evolve to liver fibrosis …