Hyperhomocysteinemia is independently associated with the development of coronary,
cerebral and peripheral vascular disease and deep-vein thrombosis in the general population. …

The sleep disorder narcolepsy is linked to the HLA-DQB1*0602 haplotype and dysregulation
of the hypocretin ligand-hypocretin receptor pathway. Narcolepsy was associated with …

Cardiovascular involvement is common in connective tissue diseases (CTD), with relevant
implications in terms of morbidity and mortality. Rhythm disturbances, ie conduction defects …

Statins are widely used hypocholesterolemic drugs that inhibit 3‐hydroxy‐3‐methylglutaryl‐coenzyme
A (HMG‐CoA) reductase, a rate‐limiting enzyme of the mevalonate pathway …

Background Cannabinoids modulate fibrogenesis in scleroderma. Ajulemic acid (AjA) is a
non-psychoactive synthetic analogue of tetrahydrocannabinol that can bind the peroxisome …

Despite the very high benefit-to-risk ratio of vaccines, the fear of negative side effects has
discouraged many people from getting vaccinated, resulting in the reemergence of previously …

This paper deals with the possible identification of somatic and autonomic nerve damage in
patients with peripheral obliterative arterial disease (POAD) at different stages of the disease…

evaluated in the clinical models of transient ischemic attack (TIA) and stroke, respectively—acutely
raise plasma adenosine levels. We studied 20 patients: 10 with TIA and 10 with stroke…

Recurrences develop in up to 20–50% of patients with acute pericarditis. Although different
causes of recurrent pericarditis have been identified, the etiology remains obscure in most …

Objectives: Matrix metalloproteinases (MMPs) produced by chondrocytes play a role in the
development of cartilage degradation in joint diseases. Moreover, inhibition of MMP secretion …