It currently is believed that scleroderma is a complex polygenic disease that occurs in genetically
predisposed individuals who have encountered specific environment exposures and/or …

Systemic sclerosis (SSc) is an autoimmune disease characterized by fibrosis of the skin and
internal organs that leads to profound disability and premature death. To identify new SSc …

Objective. To obtain a global view of the immunological alterations occurring in early systemic
sclerosis (SSc) by transcriptional profiling of peripheral blood cells (PBCs). Methods. …

The aim of this study was to determine, through a genome-wide association study (GWAS),
the genetic components contributing to different clinical sub-phenotypes of systemic sclerosis …

In this study, 1,833 systemic sclerosis (SSc) cases and 3,466 controls were genotyped with
the Immunochip array. Classical alleles, amino acid residues, and SNPs across the human …

Objective To determine the relative contributions of genetic, clinical, serologic,
sociodemographic, and behavioral/psychological variables to early pulmonary involvement in the …

Objective To determine human leucocyte antigen-class II (HLA-class II) (DRB1, DQB1,
DQA1 and DPB1) alleles, haplotypes and shared epitopes associated with scleroderma (systemic …

The etiology of scleroderma or systemic sclerosis (SSc) remains elusive despite significant
advances in the understanding of the pathogenic mechanisms of the disease since its initial …

Objective To investigate peripheral blood (PB) cell transcript profiles of systemic sclerosis (SSc)
and its subtypes in direct comparison with systemic lupus erythematosus (SLE). Methods …

Objective To determine whether biopsy specimens obtained from systemic sclerosis (SSc)
lesions show a distinctive gene profile, whether that gene profile is maintained in fibroblasts …