Objectives To describe the baseline characteristics of SLE patients requiring biologic therapy
in the UK and to explore short term efficacy and infection rates associated with rituximab (…

Endothelial microparticles (EMPs) are endothelium-derived submicron vesicles that are
released in response to diverse stimuli and are elevated in cardiovascular disease, which is …

Objective. The aim of this study was to explore the role of cytokines in the pathogenesis of
SLE in a genetically homogeneous Caucasian SLE patient population. Methods. Serum levels …

Background Patients with SLE display marked clinical and immunlogical heterogeneity. The
purpose of the study was to investigate patterns of serum cytokines in patients with active …

Objective. The overall aim of this study is to identify clinical and serological features that are
associated with B lymphocyte stimulator (BLyS) elevation in a homogeneous Caucasian …

Severe lung inflammation and alveolar hemorrhage can be life-threatening in systemic lupus
erythematosus (SLE) patients if not treated early and aggressively. Neutrophil influx is the …

Background Patients with inflammatory arthritis are at increased risk of infection. Much of
the burden of infection in this population is vaccine preventable. A number of international …

Background The definition of remission in systemic lupus erythematosus (SLE) remains
unclear, especially how background treatment should be interpreted. Objective To determine …

Objectives To investigate the relationships between interferon alpha (IFNα) and the clinical
and serological phenotype of patients with systemic autoimmune rheumatic disease (SARDs) …

Objective 10-year cardiovascular disease (CVD) risk scores are calculated using algorithms,
including Framingham (worldwide) and QRISK2 (UK). Recently, an updated QRISK3 model …