The role of B cells in lupus pathogenesis

E Nashi, YH Wang, B Diamond - The international journal of biochemistry & …, 2010 - Elsevier
Autoantibodies clearly contribute to tissue inflammation in systemic lupus erythematosus. In
order to therapeutically target B cells making pathogenic autoantibodies, it is necessary to …

Coexpression of TIGIT and FCRL3 identifies Helios+ human memory regulatory T cells

K Bin Dhuban, E d'Hennezel, E Nashi… - The Journal of …, 2015 - journals.aai.org
Two distinct subsets of CD4+ Foxp3+ regulatory T (Treg) cells have been described based
on the differential expression of Helios, a transcription factor of the Ikaros family. Efforts to …

CSK regulatory polymorphism is associated with systemic lupus erythematosus and influences B-cell signaling and activation

…, J Freudenberg, DH Ballard, E Nashi… - Nature …, 2012 - nature.com
The c-Src tyrosine kinase, Csk, physically interacts with the intracellular phosphatase Lyp (encoded
by PTPN22) and can modify the activation state of downstream Src kinases, such as …

Lupus regulator peptide P140 represses B cell differentiation by reducing HLA class II molecule overexpression

…, JF Kleinmann, M Faludi, EP Nashi… - Arthritis & …, 2018 - Wiley Online Library
Objective Phosphopeptide P140 (Lupuzor) is an inhibitor of autophagy currently being
evaluated in late‐stage clinical trials for the treatment of lupus. This study was undertaken to …

Retinal complications in patients with systemic lupus erythematosus treated with antimalarial drugs

…, CA Pineau, E Vinet, AE Clarke, E Nashi… - The Journal of …, 2020 - jrheum.org
Objective. Hydroxychloroquine (HCQ) and chloroquine (CQ) are key drugs in systemic lupus
(SLE) and related diseases. Retinal toxicity remains the most worrisome complication. We …

Development of myasthenia gravis in systemic lupus erythematosus

N Kigawa, C Pineau, A Clarke, E Nashi… - European Journal of …, 2014 - test.ejcrim.com
Materials and methods: We searched MEDLINE and PubMed for case reports of SLE and
MG. We also calculated MG incidence within our clinical SLE cohort (females only). Results: …

Retinal complications in systemic lupus erythematosus patients treated with antimalarial drugs

…, CA Pineau, E Vinet, AE Clarke, E Nashi… - The Journal of …, 2019 - jrheum.org
Objective Hydroxychloroquine (HCQ) and chloroquine (CQ) are key drugs in systemic lupus
(SLE) and related diseases. Retinal toxicity remains the most worrisome complication. We …

B cell hyporesponsiveness and autoimmunity: a new paradigm

C Grimaldi, E Nashi, J Venkatesh… - … of Lymphocyte Activation …, 2007 - Springer
Systemic lupus erythematosus (SLE) is a disease caused by autoantibodymediated damage
in multiple target organs. The hallmark autospecificity in SLE is nuclear antigen with double …

Standards are poor

E Nashi - The Journal of Allergy and Clinical Immunology: In …, 2023 - jaci-inpractice.org
To the Editor: It was inspiring to see Sanchez et al 1 hold the allergy community to a higher
standard by using the data of Kolkhir et al 2 to determine the sensitivity, specificity, positive …

Yoga in systemic lupus erythematosus: results of a pragmatic trial

…, AE Clarke, D Da Costa, EP Nashi… - Journal of …, 2014 - synergypublishers.com
Objective: To evaluate the feasibility and potential benefits of initiating a yoga program
adapted for persons with systemic lupus erythematosus (SLE). Methods: We conducted a …