Objective. To estimate and project the number of people affected worldwide by giant cell
arteritis (GCA) by 2050. Modeling the number of people visually impaired as a result of this …

Background Giant cell arteritis (GCA) is a systemic granulomatous vasculitis, primarily
affecting medium-large arteries. It has a predilection for the aorta and its major branches, …

Cybrid technology was used to replace Leber hereditary optic neuropathy (LHON) causing
mitochondrial DNA (mtDNA) mutations from patient-specific fibroblasts with wildtype mtDNA, …

Patient-specific induced pluripotent stem cells (iPSCs) have tremendous potential for
development of regenerative medicine, disease modeling, and drug discovery. However, the …

Objective Previous studies, although inconclusive, have suggested possible associations of
environmental risk factors with the development of giant cell arteritis (GCA). We aim to …

The ability to generate human induced pluripotent stem cells (iPSCs) has opened new
avenues for human disease modelling and therapy. The aim of our study was to determine …

Background Giant cell arteritis (GCA) is the most common form of vasculitis affecting elderly
people. It is one of the few true ophthalmic emergencies but symptoms and signs are …

Background Conducting ethically grounded research is a fundamental facet of all investigations.
Nevertheless, the administrative burdens of current ethics review are substantial, and …

Giant cell arteritis (GCA) is one of the commonest forms of vasculitis in the elderly, and may
result in blindness and stroke. The pathogenesis of GCA is not understood, although …

A71-year-old woman presented with re-duced vision in her right eye. She also reported
having a headache, scalp tenderness and pain in her jaw when chewing. On funduscopy, …