[PDF][PDF] Deciphering osteoarthritis genetics across 826,690 individuals from 9 populations

…, M Teder-Laving, AH Skogholt, C Terao, E Zengini… - Cell, 2021 - cell.com
Osteoarthritis affects over 300 million people worldwide. Here, we conduct a genome-wide
association study meta-analysis across 826,690 individuals (177,517 with osteoarthritis) and …

Identification of new therapeutic targets for osteoarthritis through genome-wide analyses of UK Biobank data

…, J Zheng, T Johnson, M Koprulu, E Zengini… - Nature …, 2019 - nature.com
Osteoarthritis is the most common musculoskeletal disease and the leading cause of
disability globally. Here, we performed a genome-wide association study for osteoarthritis (77,052 …

The genetic epidemiological landscape of hip and knee osteoarthritis: where are we now and where are we going?

E Zengini, C Finan, JM Wilkinson - The Journal of rheumatology, 2016 - jrheum.org
Osteoarthritis (OA) is a complex disease that affects the whole joint, with multiple biological
and environmental factors contributing to its development. The heritable component for …

[HTML][HTML] Low-frequency and rare exome chip variants associate with fasting glucose and type 2 diabetes susceptibility

…, E Tsafantakis, S Javad, LR Yanek, E Zengini… - Nature …, 2015 - nature.com
Fasting glucose and insulin are intermediate traits for type 2 diabetes. Here we explore the
role of coding variation on these traits by analysis of variants on the HumanExome BeadChip …

Genome-wide analyses using UK Biobank data provide insights into the genetic architecture of osteoarthritis

E Zengini, K Hatzikotoulas, I Tachmazidou… - Nature …, 2018 - nature.com
Osteoarthritis is a common complex disease imposing a large public-health burden. Here,
we performed a genome-wide association study for osteoarthritis, using data across 16.5 …

[HTML][HTML] Evidence for genetic contribution to the increased risk of type 2 diabetes in schizophrenia

S Hackinger, B Prins, V Mamakou, E Zengini… - Translational …, 2018 - nature.com
The epidemiologic link between schizophrenia (SCZ) and type 2 diabetes (T2D) remains
poorly understood. Here, we investigate the presence and extent of a shared genetic …

Evaluation of shared genetic aetiology between osteoarthritis and bone mineral density identifies SMAD3 as a novel osteoarthritis risk locus

…, K Trajanoska, U Styrkarsdottir, E Zengini… - Human molecular …, 2017 - academic.oup.com
Osteoarthritis (OA) is a common complex disease with high public health burden and no
curative therapy. High bone mineral density (BMD) is associated with an increased risk of …

[HTML][HTML] Genome-wide association study of developmental dysplasia of the hip identifies an association with GDF5

…, V Limbani, J Steinberg, E Zengini… - Communications …, 2018 - nature.com
Developmental dysplasia of the hip (DDH) is the most common skeletal developmental
disease. However, its genetic architecture is poorly understood. We conduct the largest DDH …

[HTML][HTML] Genetic characterization of Greek population isolates reveals strong genetic drift at missense and trait-associated variants

…, M Mezzavilla, Y Chen, C Kiagiadaki, E Zengini… - Nature …, 2014 - nature.com
Isolated populations are emerging as a powerful study design in the search for low-frequency
and rare variant associations with complex phenotypes. Here we genotype 2,296 samples …

A novel variant in GLIS3 is associated with osteoarthritis

E Casalone, I Tachmazidou, E Zengini… - Annals of the …, 2018 - ard.bmj.com
Objectives Osteoarthritis (OA) is a complex disease, but its genetic aetiology remains poorly
characterised. To identify novel susceptibility loci for OA, we carried out a genome-wide …