Objective To provide a single source for the best available estimates of the national
prevalence of arthritis in general and of selected musculoskeletal disorders (osteoarthritis, …

Background We evaluated the safety and efficacy of etanercept, a soluble tumor necrosis
factor receptor (p75):Fc fusion protein, in children with polyarticular juvenile rheumatoid …

Objective. To identify a core set of outcome variables for the assessment of children with
juvenile arthritis (JA), to use the core set to develop a definition of improvement to determine …

Background Tumor necrosis factor (TNF) has a pathogenic role in juvenile rheumatoid
arthritis. We evaluated the efficacy and safety of adalimumab, a fully human monoclonal anti-TNF …

OBJECTIVE: To develop preliminary criteria for inactive disease and clinical remission for
select categories of juvenile idiopathic arthritis (JIA), and to decide what such clinical states …

Background. The antimetabolite methotrexate has been shown in placebo-controlled trials
to be effective in adults with rheumatoid arthritis. Methotrexate may also be effective in …

Background Some children with juvenile idiopathic arthritis either do not respond, or are
intolerant to, treatment with disease-modifying antirheumatic drugs, including anti-tumour …

Objective To evaluate the safety and efficacy of infliximab in the treatment of juvenile rheumatoid
arthritis (JRA). Methods This was an international, multicenter, randomized, placebo‐…

Objective To prospectively validate the preliminary criteria for clinical inactive disease (CID)
in patients with select categories of juvenile idiopathic arthritis (JIA). Methods We used the …

… Giannini has been awarded a research grant (to Children's Hospital Medical Center) from
… Giannini has been awarded a research grant (to Children's Hospital Medical Center) from …