Hyperproduction of IL-23 and IL-17 in patients with systemic lupus erythematosus: implications for Th17-mediated inflammation in auto-immunity
IL-23-dependent IL-17-producing T helper (Th) lymphocytes are associated with autoimmunity.
We investigated the immunopathological mechanisms for activation of Th17 cells of …
We investigated the immunopathological mechanisms for activation of Th17 cells of …
Serum and urinary cell–free MiR-146a and MiR-155 in patients with systemic lupus erythematosus
Objective. Recent studies showed that micro-RNA play important roles in the pathogenesis
of autoimmune diseases. We studied the levels of miR-146a and miR-155 in the serum and …
of autoimmune diseases. We studied the levels of miR-146a and miR-155 in the serum and …
Glomerular and tubulointerstitial miR‐638, miR‐198 and miR‐146a expression in lupus nephritis
…, EKM LI, KAIM CHOW, G Wang, PKAMTAO LI… - …, 2012 - Wiley Online Library
Aim: MicroRNAs (miRNAs) play important roles in the pathogenesis of autoimmune
diseases. We studied the intra‐renal expression of miRNA targets that were reported to be …
diseases. We studied the intra‐renal expression of miRNA targets that were reported to be …
Elevated gene expression of Th1/Th2 associated transcription factors is correlated with disease activity in patients with systemic lupus erythematosus.
OBJECTIVE: T-box expressed in T cells (T-bet) and GATA-binding protein 3 (GATA-3) are
transcriptional factors that play a crucial role in Th1 and Th2 development. We investigated the …
transcriptional factors that play a crucial role in Th1 and Th2 development. We investigated the …
Anti-inflammatory activities of Chinese herbal medicine sinomenine and Liang Miao San on tumor necrosis factor-α-activated human fibroblast-like synoviocytes in …
…, KP Fung, C Bik-San Lau, CP Lau, EKM Li… - Journal of …, 2011 - Elsevier
AIM OF THE STUDY: Sinomenine, an alkaloid isolated from the root of Sinomenium acutum,
has been used to alleviate the symptoms of rheumatic diseases. Liang Miao San (LMS), …
has been used to alleviate the symptoms of rheumatic diseases. Liang Miao San (LMS), …
The gene expression of type 17 T-helper cell-related cytokines in the urinary sediment of patients with systemic lupus erythematosus
…, FMM Lai, EKM Li, G Wang, KM Chow, PKT Li… - …, 2009 - academic.oup.com
Objective. We studied the role of type 17 Th cells (TH17) in the pathogenesis of SLE. Methods.
We quantified the mRNA expression of IL-17, -23, -27 and retinoic-acid-related orphan …
We quantified the mRNA expression of IL-17, -23, -27 and retinoic-acid-related orphan …
Expression of miR-146a and miR-155 in the urinary sediment of systemic lupus erythematosus
…, BCH Kwan, EKM Li, KM Chow, CCW Luk, PKT Li… - Clinical …, 2012 - Springer
We studied the levels of miR-146a and miR-155 in the urine sediment of SLE patients. The
levels of miR-146a and miR-155 in the urine sediment of 40 SLE patients who were receiving …
levels of miR-146a and miR-155 in the urine sediment of 40 SLE patients who were receiving …
Intrarenal cytokine gene expression in lupus nephritis
Background: Lupus nephritis is characterised by intrarenal inflammation and lymphocyte
activation. Aim: To examine the profile of cytokine gene expression in glomerulus and …
activation. Aim: To examine the profile of cytokine gene expression in glomerulus and …
High prevalence of subclinical left ventricular dysfunction in patients with psoriatic arthritis
…, GWK Yip, JE Sanderson, Q Zhang, EKM Li… - The Journal of …, 2011 - jrheum.org
Objective. Endothelial dysfunction and early atherosclerosis have been found in patients
with psoriatic arthritis (PsA) without cardiovascular disease (CVD) risk factors. Few studies …
with psoriatic arthritis (PsA) without cardiovascular disease (CVD) risk factors. Few studies …
Testing scaling assumptions, reliability and validity of medical outcomes study short-form 36 health survey in psoriatic arthritis
Objectives. The Medical Outcome Survey short-form 36 (SF-36) is widely used in studies of
PsA. We test the fundamental scaling assumptions for the validity of SF-36 eight scales and …
PsA. We test the fundamental scaling assumptions for the validity of SF-36 eight scales and …